Adolescent morphine induces emotional signs of withdrawal paired with neurotoxicity selectively in male rats: female resilience

In conclusion, morphine administration during adolescence induced persistent changes in negative affect and brain toxicity selectively in male rats, suggesting female rats were resilient to these harmful effects. Given the widespread availability and use of opiate-based painkillers, the interplay between addiction, analgesia and emotional behaviors, and since adolescents and young adult humans are the age group with the highest abuse potential, these results add to the current literature by reporting distinct sex-specific opioid actions when administered in adolescence.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research

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Opioid withdrawal is one of the more uncomfortable parts of treatment, but it is one of the most important. There are many signs of opioid withdrawal, the length and severity of which can vary from person to person. However, each detox experience almost always includes strong cravings. Symptoms can be mild, such as sweating and yawning, while others can become more serious, like severe anxiety and depression. Opioid withdrawal can look like a scary experience; one that could deter people from getting the help they need. The good news is that it doesn’t need to be fought alone, and there are resources available to ma...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery Detox Resources for Alcohol and Drugs/Opiates drug detox medical detox medicated-assisted detox opioid opioids prescription drug detox withdrawal withdrawal symptoms Source Type: blogs
Astudy in theJournal of Substance Abuse Treatment has shown that treating patients with opioid use disorder (OUD) with monthly injections of extended-release buprenorphine may result in measurable improvements in patients ’ quality of life and sense of well-being. This represents a departure from standard research on OUD treatment, which largely focuses on how long patients remain in treatment and whether they abstain from illicit opioid use, according to the researchers.“Outcomes that are easily measurable during office visits can help clinicians assess life changes reflective of a person’s recovery&mdas...
Source: Psychiatr News - Category: Psychiatry Tags: buprenorphine extended-release Journal of Substance Abuse Treatment patient satisfaction quality of life Walter Ling Well-Being Source Type: research
The opioid crisis is known as the health crisis surrounding prescription, and nonprescription, opioid drugs. The overdose and death rates of opioids are climbing exponentially and the use of the drug is more rampant now than ever. How Did the Opioid Crisis Begin? In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to prescription opioid pain relievers, and healthcare providers began to prescribe them at greater rates. Before long, this lead to the medications becoming misused and it became apparent that these medications were indeed highly addictive. However,...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Heroin Addiction Recovery opioid opioid crisis opioids pharmaceutical addiction pharmaceutical drug abuse treatment pharmacists Source Type: blogs
The largest risks that come with using opioids are addiction and overdose. An overdose occurs when the body has received too much of a substance or a combination of substances. An opioid overdose can be fatal, which makes it important for all individuals to know the signs of one and what to do if it happens. What Happens During an Opioid Overdose? Opioid overdose can occur at any time, even if the opioids are being used as directed and as prescribed. Doctors can accidentally over-prescribe medications or the body can have a reaction that wasn’t expected. Opioids are a depressant, meaning they slow down the central n...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Heroin Painkiller Substance Abuse drug overdose heroin addiction heroin users opiates opioid opioids prescription drug abuse prescription drug addiction prescription medication Source Type: blogs
Publication date: 20 November 2019Source: Neuron, Volume 104, Issue 4Author(s): Margarita Calvo, Alexander J. Davies, Harry L. Hébert, Greg A. Weir, Elissa J. Chesler, Nanna B. Finnerup, Roy C. Levitt, Blair H. Smith, G. Gregory Neely, Michael Costigan, David L. BennettNeuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is both common and disabling, rendering an urgent need for non-addictive, effective new therapies. Given the high evolutionary conservation of pain, investigative approaches from Drosophila mutagenesis to human Mendelian genetics have aided our understanding of the ma...
Source: Neuron - Category: Neuroscience Source Type: research
Background: Over the last years, the use of chronic noninvasive ventilation (NIV) has increased. However, compliance rates with this therapy vary and factors influencing compliance still remain unclear.Aim: The aim of is this study was to investigate which factors influence compliance to NIV.Method: Data was retrospectively collected from adults initiated on chronic NIV (Jan ‘15 - May ‘17). Compliance rates were collected within 5-10 months after initiating on NIV. The influence of demographic characteristics, diagnosis, comorbidities and therapy-related factors on compliance (≥5 hours/day or
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Noninvasive ventilatory support Source Type: research
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
While recreational marijuana is legal in 11 states as of November 2019, more states gravitating toward legalizing the recreational use of the substance, and 33 states allowing medical marijuana, there’s apparently no stopping this trend. Cannabis, in the form of marijuana, hemp, and cannabidiol (CBD)  is being used for pain relief, to alleviate stress, cope with anxiety, and a number of other mental health disorders and addictions. Yet, there’s a dearth of clinical studies that have been conducted on the overall effects on a user’s health. Clearly, as Crain’s Detroit Business points out, more ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Medications Substance Abuse Cannabis Marijuana Source Type: blogs
Your Guide to Vicodin Addiction and Vicodin Withdrawal Hydrocodone (also known by the brand name Vicodin®) has been the second-most commonly encountered opioid pharmaceutical in drug evidence since 2009, as reported by the Drug Enforcement Administration (DEA). Withdrawal from Vicodin can vary in length and symptoms depending on the length and severity of the addiction. Vicodin is relatively easy to obtain and is perceived as safe when prescribed by a medical professional. If the drug is taken as prescribed for a limited time, Vicodin withdrawal symptoms will be either minimal or nonexistent. However, Vicodin is consid...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery Drug Treatment Painkiller Substance Abuse painkillers prescription drug abuse prescription drug addiction prescription drug detox prescription drug use prescription drugs prescription medication prescription pills Source Type: blogs
AbstractPurpose of ReviewKratom (Mitragyna speciosa) is an herb with no current indication for medical use with potentially addictive properties, yet it is being used in the management of pain, depression, and anxiety. The agent ’s pharmacology lends itself for concern regarding recreational misuse (Drugs of Abuse,2017).Recent FindingsKratom ’s increasing popularity for use in the USA is reflected by National Poison Data System data that in 2011 there were 13 cases reported to poison control centers while in 2017 there were 682 calls in response to kratom exposure (Kratom exposure in the US linked to serious me...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
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