Chronic ethanol exposure facilitates facial-evoked MLI-PC synaptic transmission via nitric oxide signaling pathway in vivo in mice

Publication date: Available online 16 November 2019Source: Neuroscience LettersAuthor(s): Na Sun, Bing-Xue Li, Guang-Hui Dong, Da-Yong Li, Bai-Ri Cui, De-Lai Qiu, Song-Biao Cui, Chun-Ping ChuAbstractEthanol (EtOH) exposure causes alterations of motor coordination, balance, behavior, speech, and certain cognitive functions are considered to be caused partly by impairment of cerebellar circuits function and modulation of synaptic transmission. The cerebellar cortical molecular layer interneuron-Purkinje cell (MLI-PC) synapses are critical for various information integration and transmission, which are sensitive to acute and chronic EtOH exposure. The aim of this study is to investigate the effect of chronic ethanol exposure on the facial stimulation-evoked MLI-PC synaptic transmission in urethane-anesthetized mice, by electrophysiological recording and pharmacological methods. Under current-clamp recording conditions, air-puff stimulation of ipsilateral whisker pad evoked MLI-PC synaptic transmission, which expressed an inhibitory component (P1) followed by a pause of simple spike (SS) firing in cerebellar PCs. Chronic ethanol exposure did not change the latency of the facial stimulation-evoked responses in cerebellar PCs, but induced significant enhancement of the stimulation-evoked MLI-PC synaptic transmission, which expressed increases in amplitude of P1 and pause of SS firing. The amplitude of P1 and pause of SS in ethanol exposure group were significant higher than that in...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research

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Abstract OBJECTIVE: The purpose of this study was to describe typical anesthesia practices for children with obstructive sleep apnea (OSA). STUDY DESIGN: Online survey. METHOD: A sample of pediatric anesthesiologists received the survey by email. RESULTS: 110 respondents were included. 46.4% worked in a free-standing children's hospital and 32.7% worked in a children's facility within a general hospital. 73.6% taught residents. 44.4% saw at least one child with OSA per week, 25.5% saw them daily. On a 100-mm visual analog scale, respondents rated their comfort with managing these children as 84.94 (...
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
Authors: Udupi S, Puri K Abstract Background: Mis-transfusion of blood components triggering serious complications are mostly due to preventable clerical errors, especially pre-transfusion misidentification of patient/blood unit at bedside. Recommendations for standard identity check is by electronic devices like barcode scanners. Establishments unable to afford these gadgets (e.g. economically poorer countries) perform identity check subjectively through visual judgement. This is prone to errors precipitating tremendous anxiety in personnel transfusing blood unit. Hence a novel objective method for pre-transfusion...
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
At the RSNA 2019 conference in Chicago, Canon Medical showed off its brand new Aquilion ONE / PRISM Edition spectral CT scanner, a system that takes advantage of artificial intelligence technologies. The device relies on Canon’s Advanced int...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Critical Care Diagnostics Emergency Medicine Neurology Ob/Gyn Oncology Radiology Source Type: blogs
Publication date: Available online 6 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Hiroki Murai, Hiroto Suzuki, Hirochi Tanji, Tomoki Kimura, Yoshinori IbaAbstractWe investigated the effects of sleep-inducing agents with different mechanisms of action on the loss of the righting reflex induced by isoflurane or a mixture of medetomidine, midazolam, and butorphanol (MMB), followed by atipamezole reversal. Chlorpromazine and brotizolam delayed recovery from both types of anesthesia, whereas the melatonin receptor agonist ramelteon had no effect. The orexin receptor antagonist suvorexant delayed recovery f...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 6 December 2019Source: Trends in Anaesthesia and Critical CareAuthor(s): Amr Elkouny, Mohamed Al-Harbi, Vassilios Dimitirou, Ali Muzafar, Ali Nawaz, Amel FayedAbstractBackgroundObstructive Sleep Apnea (OSA) is a serious condition that is usually undiagnosed in surgical patients exposing them to complications such as difficult intubation.ObjectivesTo evaluate the updated STOP-Bang in detecting OSA risk and its perioperative implications.MethodsPreoperative assessment for OSA risk of 845 adult patients using the updated STOP-Bang questionnaire was conducted. Evaluation of anesthetic events ...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Conditions:   Bone Fracture;   Opioid Use;   Opioid Dependence Interventions:   Other: SOC Pain Management;   Procedure: Early US Guided Nerve Block Administration Sponsor:   Wayne State University Recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Anesthesia;   Tolerance Intervention:   Drug: Sevoflurane Sponsor:   University of Chile Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Postoperative Cognitive Dysfunction Interventions:   Drug: Adjustment of general anesthesia;   Device: EEG monitoring Sponsor:   Dartmouth-Hitchcock Medical Center Not yet recruiting
Source: - Category: Research Source Type: clinical trials
We present a case of a gentleman with refractory postherpetic neuralgia in the intercostobrachial nerve distribution that was successfully treated with cryoneurolysis/cryoanalgesia therapy. PMID: 31802935 [PubMed]
Source: Local and Regional Anesthesia - Category: Anesthesiology Tags: Local Reg Anesth Source Type: research
CONCLUSIONS: This case series demonstrates that the use of a high frequency jet ventilator for cardiac MRI was feasible, safe, providing good quality cardiac imaging and avoiding anesthesia personnel to be inside the hazardous environment of MRI room. Future studies are needed to confirm its safety and efficiency in pediatric patients. PMID: 31796302 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
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