Long-Term Administration of High-Dose Methylphenidate-Induced Cerebellar Morphology and Function Damage in Adult Rats

Publication date: Available online 15 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Amir Raoofi, Abass Aliaghaei, Mohammad-Amin Abdollahifar, Mahdi Eskandarian Boroujeni, Sara Sadat javadinia, Hadi Atabati, Beheshteh AbouhamzehAbstractBackground and AimStated in previous studies, physicians are typically prescribing methylphenidate (MPH), commonly known as Ritalin, for children diagnosed with attention deficit hyperactivity disorder (ADHD). Nevertheless, researchers have not still understood mechanisms of this stimulant medication. Research has also found an association between apoptosis signaling pathway, neurological disorder, as well as treatment targets for neurological diseases. Therefore, the present study investigated effects of 3-week Ritalin oral (20 mg/kg) administration versus vehicle therapy on cerebellar morphology and function in adult male rats.Materials and MethodsA total number of 30 adult male rats were randomly but equally divided into control and treatment groups. In fact, the treatment group was administered by Ritalin at doses of 20 mg/kg for 21 days and the control group only received saline. At the end of weeks 1, 2, and 3 following drug treatment, rotarod performance test was fulfilled. Once the study ended, tissues of the cerebellum were separated; then, inflammation parameters (i.e. tumor necrosis factor [TNF- α] and interleukin 1 beta [IL-1β]), pro-apoptotic genes (that is, bcl-2-associated X [bax] and cas...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Authors: Şair YB, Sevinçok D, Kutlu A, Çakaloz B, Sevinçok L Abstract We investigated whether the affective temperaments of mothers and maternal depression before and during the index pregnancy are related to the development of Attention-Deficit Hyperactivity Disorder (ADHD) in their children. One hundred and twenty children were screened for the diagnosis of ADHD. After exclusion and inclusion criteria were applied for children and their mothers, we compared the mothers of children with (n = 63) and without ADHD (n = 60) in terms of affective temperament traits, de...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent disorder characterized by symptoms of inattention, hyperactivity, and/or impulsivity, as well as executive dysfunction. Recent work underlines the importance in understanding the role of emotio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The relationship between attention-deficit/hyperactivity disorder (ADHD) and the risk of alcohol abuse is widely studied. Even though this topic has been of interest for several years, it is heavily debated. We studied various papers and conducted a system...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Many people suffer from an inability to focus on tasks that require a great deal of attention. Drugs such as Ritalin are available to help mitigate symptoms of attention-deficit/hyperactivity disorder (ADHD) and related conditions, but these medicati...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Psychiatry Source Type: blogs
MONDAY, Dec. 9, 2019 -- The effect of omega-3 fish oil supplements on cognitive symptoms in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) may vary according to endogenous levels of eicosapentaenoic acid (EPA),...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
AbstractSocial networking sites (SNSs) are now used by billions of users worldwide and can help facilitate communication and the sharing of information. However, there is evidence that problematic SNS use (PSNSU) can have negative effects on health. The present study examined the associations between PSNSU, sleep quality, attention-deficit/hyperactivity disorder (ADHD), depression, anxiety and stress among SNS users. A total of 638 SNS users (mean age  = 32.03 years, SD = 10.08) completed an online survey comprising instruments assessing SNS addiction, sleep quality, ADHD, depression, anxie...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
CONCLUSION: The PRS for schizophrenia was not associated with CUD in controls or patients with other psychiatric disorders than schizophrenia. This speaks against the hypothesis that shared genetic vulnerability would explain the association between cannabis and schizophrenia. PMID: 31813396 [PubMed - as supplied by publisher]
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Translational Psychiatry, Published online: 09 December 2019; doi:10.1038/s41398-019-0679-zStructural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
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Source: Canadian Journal of Psychiatry - Category: Psychiatry Authors: Tags: Can J Psychiatry Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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