The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases.

The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases. Curr Pharm Des. 2019 Nov 12;: Authors: Tu C, He J, Chen R, Li Z Abstract Exosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs) have emerged as novel potential biomarkers or disease-targeting agents in a variety of diseases. However, the shortage of effective delivery system may impair their clinical application. Recently, accumulating evidences have demonstrated that ncRNAs could be efficiently delivered to recipient cells using exosomes as a carrier, and thereby exerting a critical role in musculoskeletal diseases including osteoarthritis, rheumatoid arthritis, osteoporosis, muscular dystrophies, osteosarcoma and other diseases. Herein, we made an extensive review on the biogenesis, physiological relevance and clinical implication of exosome-derived ncRNAs in musculoskeletal diseases. PMID: 31724510 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research