Cymbopogon schoenanthus (Ethkher) ameliorates cadmium induced toxicity in swiss albino mice

Publication date: November 2019Source: Saudi Journal of Biological Sciences, Volume 26, Issue 7Author(s): Shalini Saggu, Hasibur Rehman, Al Thbiani Aziz, Fahad M.A. Alzeibr, Atif Abdulwahab A. Oyouni, Nahla Zidan, Chellasamy Panneerselvam, Subrata TrivediAbstractCadmium is among the toxic and hazardous metal widely dispersed in the environment in high levels. Current studies have provided new insights into antioxidant properties of bioflavonoid which have emerged as probable therapeutic and nutraceutical agents. The present study is geared to investigate the possible role of Cymbopogon schoenanthus (L.) Spreng. (or Ethkher) on heavy metal cadmium (Cd) induced oxidative stress in mice. Mice were randomly divided into four groups and treated for 15 days as follows: group 1: normal control-treated (saline); group 2: Ethkher leaves extract-treated (100 mg/kg); group 3: cadmium chloride (CdCl2) treated; group 4: CdCl2 plus Ethkher leaves extract. The results showed a significant reduction in hemoglobin, RBC and hematocrit in cadmium-treated mice as compared to control. Exposure to Cd caused a significant increase in the number of white blood cells (P < 0.05) indicating the occurrence of systemic inflammation. The results of this study also revealed that the mice intoxicated with Cd showed a significant increase in bilirubin, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) acti...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research