Molecules, Vol. 24, Pages 4151: Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones
Molecules, Vol. 24, Pages 4151: Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones
Molecules doi: 10.3390/molecules24224151
Authors:
Witold Gładkowski
Monika Siepka
Tomasz Janeczko
Edyta Kostrzewa-Susłow
Jarosław Popłoński
Marcelina Mazur
Barbara Żarowska
Wojciech Łaba
Gabriela Maciejewska
Czesław Wawrzeńczyk
Six γ-oxa-ε-lactones, 4-phenyl-3,4-dihydro-2H-1,5-benzodioxepin-2-one (5a) and its five derivatives with methoxy groups in different positions of A and B rings (5b–f), were synthesized from corresponding flavanones. Three of the obtained lactones (5b,c,f) have not been previously described in the literature. Structures of all synthesized compounds were confirmed by complete spectroscopic analysis with the assignments of signals on 1H and 13C-NMR spectra to the corresponding atoms. In most cases, lactones 5a–f exerted an inhibitory effect on the growth of selected pathogenic bacteria (Escherichia coli, Bacillus subtilis, and Staphylococcus aureus), filamentous fungi (Fusarium graminearum, Aspergillus niger, and Alternaria sp.), and yeast (Candida albicans). The broadest spectrum of activity was observed for unsubstituted lactone 5a, which was particularly active against filamentous fungi and yeast. Lactones with methoxy groups in the 3′ (5c) and 4′ (5d) position of B ring were more active towards bact...
Source: Molecules - Category: Chemistry Authors: Witold G ładkowski Monika Siepka Tomasz Janeczko Edyta Kostrzewa-Sus łow Jaros ław Popłoński Marcelina Mazur Barbara Żarowska Wojciech Łaba Gabriela Maciejewska Czes ław Wawrzeńczyk Tags: Article Source Type: research
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