Anti-influenza A (H1N1) viral and cytotoxic sesquiterpenes from Carpesium abrotanoides

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Yu-Qing He, Liang Cai, Qun-Gang Qian, Sheng-Hui Yang, Di-Lu Chen, Bi-Qing Zhao, Zhen-Ping Zhong, Xiao-Jiang ZhouAbstractTwo new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11(13)-dehydroivaxillin (3), eriolin (4), 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (5), (5α)-5-hydroxyasperilin (6), 1α,4α-dihydroxy-guaia-11(13)-ene-12,8α-olide (7) and 4α,5α-dihydroxy-guaia-11(13)-en-12,8α-lactone (8), were isolated from the herbs of Carpesium abrotanoides L. The structures of these sesquiterpenes were elucidated based on spectroscopic analysis, and single crystal X-ray diffraction analysis. All the compounds exhibited potent cytotoxicity against the ISK, Hela, A549, Sw620, RBE and Caco-2 cell lines, with IC50 values ranging from 7.8–47.4 μM. In addition, compounds 2, 3, 4, 7 and 8 displayed significant anti-influenza A (H1N1) virus activity with IC50 values of 6.2, 11.6, 16.4, 1.3 and 0.4 μM, respectively.Graphical abstract

Source: Phytochemistry Letters - November 16, 2019 Category: Chemistry Source Type: research