Monoterpenoid indole alkaloids from the fruits of Melodinus henryi

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Qian Shao, Rui Ma, Xing Wu, Fa-Lei Zhang, Zheng-Hui Li, Tao Feng, Juan He, Ji-Kai LiuAbstractFour undescribed monoterpenoid indole alkaloids, melodinines X1‒X4 (1‒4), together with fourteen known ones, have been isolated from the fruits of Melodinus henryi. Their structures with absolute configurations were elucidated by extensive spectroscopic methods and ECD calculations. Compound 1 shows a significant cytotoxicity to HL-60 cancer cell line with an IC50 value of 0.8 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research