A New Lignanamide Derivative and Bioactive Constituents of Lycium chinense

A new lignanamide derivative, lycichinenamide (1), has been isolated from the root barks ofLycium chinense together with nine known compounds, lyciumamide H (2), 5,2 ′-dihydroxy-6,7,8,6′-tetramethoxyflavone (3), 7α,8β-3 ′-O-methylcedrusin (4), smiglabrol (5),trans-N-caffeoyltyramine (6), vanillic acid (7), syringic acid (8), 2,6-dimethoxy-1,4-benzoquinone (9), and 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10). The structure of the new compound1 was determined through spectroscopic and MS analyses. Among the isolates, lycichinenamide (1), lyciumamide H (2), smiglabrol (5), andtrans-N-caffeoyltyramine (6) showed potent inhibition with IC50 values of 18.5 ± 2.1, 21.8 ± 1.8, 12.4 ± 0.3, and 24.6 ± 2.0 μM, respectively, against LPS-induced NO generation. In addition, 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10) exhibited anti-Dengue virus activity with IC50 value of 22.4 ± 1.6 μM against Dengue virus serotype 2 strain PL046.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research

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Source: The Lancet - Category: General Medicine Source Type: research
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Source: The Lancet - Category: General Medicine Source Type: research
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Source: Biologicals - Category: Biology Source Type: research
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