Anti-Influenza Activity of Several Caryophyllane Hiosesquiterpenoids

Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research

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THURSDAY, Dec. 12, 2019 -- Few child care center directors report having an influenza vaccine requirement for children and adult caregivers, according to a study published online Dec. 12 in the Journal of the Pediatric Infectious Diseases...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(Pediatric Infectious Diseases Society) Influenza can be especially dangerous for children, who are at greater risk for serious complications from the illness, including hospitalization and even death. Yet child care centers in the US rarely require children or the adults who care for them to be vaccinated against flu, according to a new study published in the Journal of the Pediatric Infectious Diseases Society.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 10 December 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alina A. Okhina, Artem D. Rogachev, Olga I. Yarovaya, Mikhail V. Khvostov, Tatyana G. Tolstikova, Andrey G. Pokrovsky, Veniamin A. Khazanov, Nariman F. SalakhutdinovAbstractA method of quantitative determination of camphecene, a new anti-influenza agent, in rat blood plasma based on LC-MS/MS was developed, validated and used to study the distribution of the agent between blood cells and blood plasma. The method was validated according to FDA and EMA recommendations in terms of selectivity, linearity, accur...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe SE damaged the cell membrane, with the cytoplasm flowing out, disturbed the synthesis of total protein and phosphorus metabolism, and ultimately killed the bacteria.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we generate a mouse strain capable of reporting IFN-signaling activated by all three types of IFNs and investigate the spatio-temporal dynamics and identity of IFN-responding cells following IFN injection and influenza virus infection. Despite ubiquitous expression of IFN receptors, cellular responses to IFNs are highly heterogenous in vivo and are determined by anatomical site, cell type, cellular preference to individual IFNs, and activation status. Unexpectedly, type I and II pneumocytes, the primary target of influenza infection, exhibit striking differences in the strength and temporal dynamics of ...
Source: Cell Reports - Category: Cytology Source Type: research
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A. We developed a novel anti-influenza A virus approach based on an engineered single-domain antibody (VHH) construct that can selectively recruit innate immune cells to the sites of virus replication. This protective construct comprises two VHHs. One VHH binds with nanomolar affinity to the conserved influenza A matrix protein 2 (M2) ectodomain (M2e). Co-crystal structure analysis revealed that the com...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Due to an unfortunate oversight the acknowledgements has been omitted.
Source: Journal of Public Health Policy - Category: Health Management Source Type: research
Publication date: Available online 10 December 2019Source: Microbial PathogenesisAuthor(s): Mohsan Ullah Goraya, Fozia Zaighum, Nelam Sajjad, Faisal Rasheed Anjum, Irfan Sakhawat, Sajjad ur RahmanAbstractInfluenza viruses cause mild to severe infections in animals and humans worldwide with significant morbidity and mortality. Infection of eukaryotic cells with influenza A viruses triggers the induction of innate immune system through the interaction between pattern recognition receptors (PRRs) and pathogen associated molecular patterns (PAMPs), which culminate in the induction of interferons (IFNs). Consequently, IFNs bind...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
by Amy Reese, PharmD, MA. Tamiflu (oseltamivir) is a neuraminidase inhibitor which decreases the viral spread of Influenza A and B. It was a revolutionary drug when it was approved by the FDA in December 2000 because it was indicated to reduce the duration and severity of both influenza viruses. It was also proven to prevent a patient from being infected with either influenza virus. The only stipulation with the medication was that its efficacy was only shown within the first 48 hours of influenza symptoms.…
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Decision making Featured Posts Health Care Health Policy & Insurance Pharmaceuticals Source Type: blogs
Condition:   Influenza Interventions:   Biological: OVX836;   Biological: Quadrivalent seasonal influenza vaccine (Influvac TetraTM) Sponsors:   Osivax S.A.S;   Centre for vaccinology (CEVAC), University of Ghent Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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