CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart.
Conclusions: The developed mouse model permits enhancement of gene expression by utilizing endogenous regulatory genomic elements. Proof-of-concept in two independent genomic loci suggests versatile applications in controlling transcription in cardiomyocytes of the postnatal heart.
PMID: 31730408 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Schoger E, Carroll KJ, Iyer LM, McAnally J, Tan W, Liu N, Noack C, Shomroni O, Salinas G, Gross J, Herzog N, Doroudgar S, Bassel-Duby R, Zimmermann WH, Zelarayan LC Tags: Circ Res Source Type: research
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