Breast-conserving surgery in breast cancer and intraoperative radiotherapy. Can we predict the fibrosis?

Publication date: Available online 16 November 2019Source: Cirugía Española (English Edition)Author(s): Cristina Vallejo Bernad, Maria del Carmen Casamayor Franco, Jesús Víctor Pérez-Tierra Ruiz, Yaiza Martínez Lahoz, Aurora Carrasquer Puyal, José Luis Pallarés Segura, Juan Pelegrín Sánchez Marín, María Victoria Barra PardosAbstractIntroductionRadiotherapy techniques associated with breast-conserving surgery have evolved in early breast cancer thanks to a better knowledge of tumor radiobiology, highlighting intraoperative radiotherapy (IORT). However, complications have been documented with this procedure, mainly fibrosis. Transforming growth factor beta (TGF-β) is a cytokine with an active role in radiation-induced fibrosis, which could be used as an early biomarker for the development of fibrosis.MethodsMulticentric prospective analysis of 60 patients with breast cancer who underwent breast-conserving surgery, 30 of whom had received additional IORT. TGF-β values were evaluated in serum pre-surgery and in serum collected 24 h after surgery. In addition, we evaluated surgical wound fluids collected 6 h and 24 h following surgery.ResultsSerum and surgical wound fluids TGF-β values collected over 24 h following surgery were significantly higher in patients who received additional IORT (P 
Source: Cirugia Espanola - Category: Surgery Source Type: research

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Conclusions: Axillary reverse mapping is a minimally invasive technique that can be performed during axillary lymph-node dissection, helping to prevent the subsequent development of arm lymphedema. Trial registration: #SCURCTN3276, retrospectively registered on 11 April 2017 at Research Ethics Committee at the Faculty of medicine-Suez Canal University. PMID: 31807140 [PubMed]
Source: Patient Safety in Surgery - Category: Surgery Authors: Tags: Patient Saf Surg Source Type: research
Publication date: Available online 5 December 2019Source: The LancetAuthor(s): Frank A Vicini, Reena S Cecchini, Julia R White, Douglas W Arthur, Thomas B Julian, Rachel A Rabinovitch, Robert R Kuske, Patricia A Ganz, David S Parda, Michael F Scheier, Kathryn A Winter, Soonmyung Paik, Henry M Kuerer, Laura A Vallow, Lori J Pierce, Eleftherios P Mamounas, Beryl McCormick, Joseph P Costantino, Harry D Bear, Isabelle GermainSummaryBackgroundWhole-breast irradiation after breast-conserving surgery for patients with early-stage breast cancer decreases ipsilateral breast-tumour recurrence (IBTR), yielding comparable results to m...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 5 December 2019Source: The LancetAuthor(s): Timothy J Whelan, Jim A Julian, Tanya S Berrang, Do-Hoon Kim, Isabelle Germain, Alan M Nichol, Mohamed Akra, Sophie Lavertu, Francois Germain, Anthony Fyles, Theresa Trotter, Francisco E Perera, Susan Balkwill, Susan Chafe, Thomas McGowan, Thierry Muanza, Wayne A Beckham, Boon H Chua, Chu Shu Gu, Mark N LevineSummaryBackgroundWhole breast irradiation delivered once per day over 3–5 weeks after breast conserving surgery reduces local recurrence with good cosmetic results. Accelerated partial breast irradiation (APBI) delivered over 1 week t...
Source: The Lancet - Category: General Medicine Source Type: research
Zhang Tam Ho : The purpose of our study was to carry out a meta-analysis of current literature to determine whether total mastectomy and breast-conserving surgery induce different outcomes in quality of life, based on the breast-cancer-specific module of the European Organizaation for Research and Treatment of Cancer core questionnaire (EORTC QLQ-BR23) used postoperatively. A systematic literature search of PubMed and EMBASE was conducted. Observational clinical studies that compared the quality of life in different surgery groups and presented empirical findings were selected. Six studies met the inclusion cri...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
CONCLUSION: Surgically treated breast cancer patients are less likely to receive short- and long-term opioid prescriptions following the implementation of hydrocodone rescheduling. Further studies on the potential impact of federal policy on cancer patient pain management are needed. IMPLICATIONS FOR PRACTICE: Clinicians and researchers with diverse perspectives should be included as stakeholders during policy development for restricting opioid prescriptions. Stakeholders can identify potential unintended consequences early and help identify methods to mitigate concerns, specifically as it relates to policy that influ...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
ConclusionsWomen with RA or BC differ substantially with respect to their subjectively assessed resources and body image when compared to women with no chronic diseases. Therefore, psychological counselling designed for females with RA or BC should be employed to help them restore the aspects altered by their respective illnesses.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS: The breast-conserving surgery had a positive impact on patients with early breast cancer. Patient who received this surgery had a lower rate of blood loss and smaller incision. The surgery duration was shorter and postoperative recovery time was shorter. Moreover, breast-conserving surgery had a better cosmetic effect. The Breast-conserving surgery is worthy of further application in the treatment of early breast cancer. PMID: 31786853 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
ConclusionsPhysician peer groups significantly influenced use of short course EBRT in adjuvant therapy but not in palliative therapy for patients with breast cancer.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Breast cancer is the most frequent non-skin cancer and the leading cause of cancer death among women [1]. Radiotherapy after breast-conserving surgery halves the rate of any recurrence and reduces the breast cancer death rate by about one sixth [2]. However, radiotherapy also increases the subsequent ischemic heart disease rate, which is linearly related to the heart dose [3]. Left-sided breast treatments are therefore often delivered during deep-inspiration breath-hold (DIBH) to reduce heart irradiation and toxicity by increasing the physical separation between the treated breast and the heart [4 –7].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: This study suggested that 'CEX' therapy as NAC could be an important option for individualized treatment. In particular, it was effective for TN breast cancer. PMID: 31776320 [PubMed - as supplied by publisher]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
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