Long-term outcome of patients with pregnancy and lactation-associated osteoporosis (PLO) with a particular focus on quality of life
ConclusionPLO has a significant impact on pain, mental state, quality of life, and capacity to work. However, the long-term prognosis is promising. The severe mental distress is presumably related to several contributing factors in life such as physical integrity and independence, family life, employment, and financial security.Key Points• PLO has a strong impact on quality of life and can lead to severe mental distress.• At onset of symptoms, patients with PLO are in very poor mental and physical condition; however, the long-term outcome after inpatient rehabilitation seems to be good.• Most patients do not suffer subsequent vertebral fractures until the menopause.
Authors: Chu Y, Ge W, Wang X Abstract MicroRNAs (miRNAs) play crucial roles in the pathogenesis of neuropathic pain. The present study investigated the effects of miR-448 on the progression of neuropathic pain in a rat model of chronic constriction injury (CCI) of the sciatic nerve. Reverse-transcription quantitative polymerase chain reaction was conducted to detect the gene expression. The paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were used to assess the pain threshold. The protein expression levels of interleukin (IL)-6, IL-1β and tumor necrosis factor-α (TNF-α) were detecte...
Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Furqan A. Maulvi, Lakshmi V. Pillai, Kajal P. Patel, Ankita R. Desai, Manish R. Shukla, Ditixa T. Desai, Hetal P. Patel, Ketan M. Ranch, Shailesh A. Shah, Dinesh O. ShahAbstractLidocaine is widely used as a local anaesthetic in the clinical practice to manage pre- and post-operative pain, skin burns, etc. However, the short duration of action (
Publication date: January 2020Source: Brain, Behavior, and Immunity, Volume 83Author(s): Elisa Brietzke, Linda Booij, Andrea Wieck, Alessandro Ricci, Claudio N. Soares, Nasreen Roberts, Sarosh Khalid-Khan
The ailment was intrahepatic cholestasis of pregnancy, which causes a toxic womb environment and can lead to stillbirths.
Conclusions: These findings suggest that among MDD patients, early experiences of emotional and physical abuse and neglect is associated with difficulties in describing feelings in adulthood. PMID: 31808358 [PubMed - as supplied by publisher]
All people are the same; only their habits differ. ~ Confucius This is a post about what keeps us stuck and sets us free, about the good news behind bad luck, and the wrong way to want the right thing: It’s about our habits. Human beings are creatures of habit — even emotionally. But why is this? Why do we fall into routines? And why is it so hard to break a habit? The short answer is something called set point. You’re probably familiar with this idea if you have ever been on a diet or had a new year’s resolution. They both start well. You are going to make a change in your life and you are ready fo...
Many patients with cognitive impairment have anxiety or depression, but standard treatments are difficult for people with memory issues.
(NYU Langone Health / NYU School of Medicine) A computer betting game can help predict the likelihood that someone recovering from opioid addiction will reuse the pain-relieving drugs, a new study shows.
Publication date: 7 December 2019Source: New Scientist, Volume 244, Issue 3259Author(s): Clare Wilson
Conclusions: We identified 19 quality indicators to measure early pregnancy care provided by EPAUs.