Isolated hypothyroxinemia in Iranian pregnant women, the role of iodine deficiency; a population based cross-sectional study.

Isolated hypothyroxinemia in Iranian pregnant women, the role of iodine deficiency; a population based cross-sectional study. Thyroid. 2019 Nov 14;: Authors: Etemadi A, Amouzegar A, Mehran L, Tohidi M, Azizi F, Moradi K, Delshad H Abstract Objective Thyroid disorders such as subclinical hypothyroidism and isolated maternal hypothyroxinemia are understudied in pregnant women, despite their possible adverse effects on the health of mother and child. Also, the role of iodine deficiency in developing such disorders has not yet been fully understood. Design The present national population-based cross-sectional study was conducted on 1080 randomly recruited pregnant women, aged 20-40 from 12 provinces of Iran from 2013 to 2014. Method Serum concentrations of TSH, T4, thyroid peroxidase antibody and T3 resin uptake values were measured in fasting blood samples, and urinary iodine concentration was measured in three separate urine samples. Multinomial logistic regression was run to analyze the possible risk factors regarding thyroid disorders. In order to clarify the role of iodine in thyroid status specifically, the determinants of UIC and its correlations with thyroid function tests were investigated independently and through subgroup analysis. Results Isolated hypothyroxinemia was the most common thyroid disorder (9.9%), followed by subclinical hypothyroidism (8%). In comparison to euthyroid pregnant women, isolated hypothyroxinemia was more likely in pregnant...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research

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Authors: Sitoris G, Veltri F, Kleynen P, Cogan A, Belhomme J, Rozenberg S, Pepersack T, Poppe K Abstract Backgound: Subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) have been associated with poor clinical pregnancy outcomes. However, these outcomes also depend on a number of demographic and obstetric variables. Therefore, the aim of the study was to investigate the impact of thyroid disorders on these outcomes, after adjustment for associated demographic and obstetrical parameters. METHODS: Cross-sectional study including 1521 pregnant women who did their work-up and follow-up in our center and h...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
ConclusionsTreatment of hypothyroidism in pregnancy should be initiated based on a TSH> 4 mIU/L. Treatment initiation based on thyroid autoimmunity or a TSH> 2.5 mIU/L may result in overtreatment.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionKagami –Ogata syndrome should have been suspected because of the presence of polyhydramnios and omphalocele during pregnancy. Respiratory insufficiency soon after birth, because of a small thorax, is expected in this disease and a diagnosis during pregnancy may have enabled appropriate care after birth.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Although 1 in 200 women with fertility issues have overt thyroid dysfunction and many more subclinical hypothyroidism, it is unclear how best to identify or manage them, say UK researchers.Medscape News UK
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
ConclusionBreech presentation in preterm labor is associated with obstetric risk factors compared to cephalic presentation. These risks decrease linearly with the gestational age. In moderate to late preterm delivery, breech presentation is a high-risk state and some obstetric risk factors are yet visible in early preterm delivery. Breech presentation in extremely preterm deliveries has, with the exception of preterm premature rupture of membranes, similar clinical risk profiles as in cephalic presentation.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
A national survey of physicians provides insight into the variation in clinical practices regarding the management of pregnant women with subclinical hypothyroidism.Journal of the Endocrine Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
ConclusionsHysteroscopy may play an important role before or in conjunction with assisted reproductive techniques to help infertile women and couples achieve their goals of pregnancy and live birth of a child.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Abstract BACKGROUND: The direct role of antiphospholipid antibodies (aPL) at maternal-fetal interface has not been fully investigated, especially whether they are involved in physiological and pathological implantation conditions, in an antiphospholipid syndrome (APS)-independent manner. In fact, trophoblast cells and placental endothelial cells at the implantation site express potential aPL targeted-phospholipid antigens (PL Ags); thus, the local production and presence of their specific antibodies, not related to APS (characterized by aPL presence in the peripheral blood), could be a potential marker of aberrant...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
This study aimed to survey the effects of rat neonatal CSF collected from induced hypothyroid mothers on differentiation of bone marrow mesenchymal stem cells (BM-MSCs). We hypothesized that hypothyroidism affected levels of growth factor in CSF. To induce hypothyroidism, pregnant Wistar rats received methimazole at the third day of gestation. BM-MSCs were obtained from rat femurs and tibias and cultured in medium. CSF was collected from the cisterna magna of newborn rats, and cells were subsequently exposed to CSF with concentrations of 5,7, and 10 /100 (v/v) for 72 h. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazo...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
Hormone replacement therapy for hypothyroidism taken during pregnancy does not increase risk for language impairments in children, according to a study published inJAMA Network Open.MedPageToday
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
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