MDM2-positive papillary sarcomatoid renal cell carcinoma: a potential diagnostic pitfall

We present a case of advanced type 1 papillary sarcomatoid renal cell carcinoma infiltrating adjacent organs and showing positivity for MDM2 by immunohistochemistry andMDM2 amplification by fluorescence in situ hybridization. This finding, together with sarcomatoid morphology, poses a potential pitfall for diagnosis with dedifferentiated liposarcoma. MDM2 is known to be altered in various human sarcomas. Only recently, MDM2 alterations have been reported in carcinomas. The presented case illustrates the need of thorough sampling with clinic-pathological correlation before making a final diagnosis in sarcomatoid retroperitoneal tumours. Additionally, the potential clinical implications ofMDM2 amplification in renal cell carcinoma are discussed.
Source: Virchows Archiv - Category: Pathology Source Type: research

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PAX8 is used as a diagnostic aid in classifying retroperitoneal (RP) spindle cell tumors. PAX8 positivity in a spindled RP tumor is typically associated with sarcomatoid renal cell carcinoma (SRCC). However, PAX8 expression in solitary fibrous tumor (SFT), a tumor not uncommon to the RP, has not been extensively studied. We investigated the expression of PAX8 in SFTs and other spindle cell RP tumors. We collected 30 SFT, 23 SRCC, 11 gastrointestinal stromal tumors, 2 synovial sarcomas, 6 dedifferentiated liposarcomas (DDLS), 4 well differentiated liposarcomas (WDLS), and select other tumors. We identified nuclear PAX8 expr...
Source: Applied Immunohistochemistry and Molecular Morphology - Category: Chemistry Tags: Research Articles Source Type: research
We report on a extremely rare case of asymptomatic perinephric dedifferentiated sclerosing liposarcoma which appeared to mimic cystic renal cell carcinoma on clinical and radiological presentation. The patient underwent a right partial nephrectomy and remains tumour free at six months follow up.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionsOur data demonstrated that metastatic clear cell renal cell carcinoma was the most common secondary tumor involving the pancreas. Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Knowing the prior history of malignancy, recognizing uncommon cytomorphologic features, and performing ancillary studies are keys to improve diagnostic accuracy.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
We report on a extremely rare case of asymptomatic perinephric dedifferentiated sclerosing liposarcoma which appeared to mimic cystic renal cell carcinoma on clinical and radiological presentation. The patient underwent a right partial nephrectomy and remains tumour free at six months follow up.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionsOur data demonstrated that metastatic clear cell renal cell carcinoma was the most common secondary tumor involving the pancreas. Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Knowing the prior history of malignancy, recognizing uncommon cytomorphologic features, and performing ancillary studies are keys to improve diagnostic accuracy.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Conclusions Our data demonstrated metastatic renal cell carcinoma was the most common secondary tumor involving the pancreas. Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Knowing the prior history of malignancy, recognizing uncommon cytomorphologic features and performing ancillary studies are keys to improve diagnostic accuracy.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
We report on a extremely rare case of asymptomatic perinephric dedifferentiated sclerosing liposarcoma which appeared to mimic cystic renal cell carcinoma on clinical and radiological presentation. The patient underwent a right partial nephrectomy and remains tumour free at six months follow up.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: - Nonmesothelial neoplasms are uncommon in individuals with MM, but certain tumor types are increased in prevalence. In an unselected study population with respect to BAP1 status, the prevalence of several tumor types described in BAP1 mutation carriers, including lung carcinoma, clear cell renal cell carcinoma, breast carcinoma, meningioma, pleomorphic undifferentiated sarcoma, and ocular melanoma, was increased. PMID: 29528717 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
We report on an extremely rare case of asymptomatic perinephric de-differentiated sclerosing liposarcoma mimicking a cystic renal cell carcinoma on clinical and radiological presentation. Difficulties in diagnosis and therapy of this rare tumor are discussed in the light of the available literature.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
Conclusion The different primaries seem to metastasize in different frequencies to the head and neck area. The relatively common prostate cancer rarely seems to produce metastases in the head and neck area compared to cancers arising in the kidneys. In case of a malignant tumour of unknown primary, osseous metastases most often are caused by breast or lung cancer or renal cell carcinoma. Soft tissue metastases are most often caused by breast cancer.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
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