Biomarkers of Alzheimer disease in mild cognitive impairment: Experience in a memory clinic from Latin America

ConclusionsThis study demonstrates biomarker-based MCI prognosis and supports its role in clinical decision-making in daily practice.ResumenObjetivoEl objetivo de este estudio fue investigar el rol y pronóstico de los biomarcadores de enfermedad de Alzheimer en pacientes con diagnóstico clínico de deterioro cognitivo leve (DCL) en una clínica de memoria de Latinoamérica.MétodoOchenta y nueve pacientes con DCL, 43 con demencia tipo Alzheimer y 18 controles normales apareados por edad, sexo y escolaridad fueron estudiados con un extenso protocolo demográfico, neurológico y neuropsicológico en la clínica de memoria del Instituto FLENI de Buenos Aires. Todos completaron una RM cerebral, una PET con FDG, una PET con estudios amiloideo (PIB), genotipificación de APOE y estudio de Aβ1-42, tau and f-tau de líquido cefalorraquídeo. Basado en la presencia/ausencia de patología amiloidea y neurodegeneración los pacientes fueron categorizados como A+/A− y N+/N− respectivamente.ResultadosEn el estudio de líquido cefalorraquídeo el 18% de los controles, el 64% de los DCL y el 92% de las demencia tipo Alzheimer tenían patología amiloidea; y un 11% de los controles, el 6% de los DCL y el 8% de las DTA eran sospechosos de fisiopatología no Alzheimer. En el seguimiento a los 30 meses el 45% de los DCL con amiloide positivo y el 20% de los ...
Source: Neurologia - Category: Neurology Source Type: research

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CONCLUSION: The low agreement between amyloid PET/CT and previous clinical and instrumental assessments that we found in our study suggests that the amyloid PET/CT provides additional and early information. To perform an early and differential diagnosis of AD could have a great impact on the patient's management and cost of care in order to perform the correct therapeutic interventions and to allow family members to manage adequately the patient's demanding care. PMID: 31802055 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
In this study, we compared three different approaches for the quantification of hippocampal [18F]flortaucipir signal using a semi-automated technique, and assessed correlations with cognitive performance across methods.Methods: Dynamic 130 minute [18F]flortaucipir PET scans were performed in 109 subjects (45 cognitively normal subjects (CN) and 64 mild cognitive impairment/Alzheimer's disease (AD) dementia patients. We extracted hippocampal binding potential (BPND) using receptor parametric mapping with cerebellar grey matter as reference region. PVC HDH was performed. Based on our previous study in which we manually erode...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This report describes the practical benefits and challenges of using integrated FDG-PET-MRI to support the clinical diagnosis of various dementias. Over the past 7 years, we have performed integrated FDG-PET-MRI on>1500 patients with possible cognitive impairment or dementia. The FDG-PET and MRI protocols are the same as current conventions, but are obtained simultaneously over 25 minutes. An additional Dixon MRI sequence with superimposed bone atlas is used to calculate PET attenuation correction. A single radiologist interprets all imaging data and generates 1 report. The most common positive finding is concordant tem...
Source: Topics in Magnetic Resonance Imaging - Category: Radiology Tags: Review Articles Source Type: research
To the Editor In their Viewpoint on preclinical Alzheimer disease (AD), Langa and Burke cite data from the Imaging Dementia —Evidence for Amyloid Scanning (IDEAS) study to support the claim that positive results on amyloid positron emission tomography (PET) scans may lead to inappropriate use of AD medications in cognitively unimpaired individuals. Following published appropriate use criteria for amyloid PET, patients enrolled in the IDEAS study were required to meet clinical criteria for mild cognitive impairment (MCI) or dementia, and individuals with unimpaired cognition were excluded from the study. Physician cho...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
DiscussionElevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
DEMENTIA, in particular Alzheimer ’s disease, effects 850,000 people in the UK. This figure is set to rise to two million by 2015. There is currently no cure for dementia, however, a new study has suggested Alzheimer’s disease could be predicted by a brain scan decades before symptoms develop.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The objectives of the present study were to investigate (1) whether trinary visual interpretation of amyloid positron emission tomography (PET) imaging (negative/equivocal/positive) reflects quantitative amyloid measurements and the time course of11C-Pittsburgh compound B (PiB) amyloid accumulation, and (2) whether visually equivocal scans represent an early stage of the Alzheimer ’s disease (AD) continuum in terms of an intermediate state of quantitative amyloid measurements and the changes in amyloid accumulation over time.MethodsFrom the National Bioscience Database Center Human Database of the Japanese Alzheimer ...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
In 2016, UC San Francisco researchers discovered mice with an Alzheimer's risk gene had fewer 'sharp-wave ripples.' Their new study suggests these memory waves can predict dementia 30 years early.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: FDG-PET-based visual and cortex ID classification has a good accuracy in predicting progression to dementia including AD in the prodromal aMCI phase. Absence of typical metabolic patterns on FDG-PET can play an important exclusionary role for progression to dementia. Vascular cognitive impairment with cerebral atrophy needs further studies to confirm and uncover potential mechanisms.
Source: Neurology India - Category: Neurology Authors: Source Type: research
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