Renalase regulates renal dopamine and phosphate metabolism.

Renalase regulates renal dopamine and phosphate metabolism. Am J Physiol Renal Physiol. 2013 Jul 17; Authors: Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV Abstract Renalase is a kidney secreted catecholamines-degrading enzyme whose expression and activity are down-regulated by increased dietary phosphate. A renalase knockout (KO) mouse model was used to explore the mechanisms mediating renalase's effect on phosphate excretion. Compared to wild type (WT) mice maintained on a regular diet, KO mice show decreased serum PO4- (KO=5.3±0.2 vs WT=6.0±0.1, n= 6, p
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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