Antifungal Resistance: a Concerning Trend for the Present and Future

AbstractPurpose of ReviewThe global emergence of antifungal resistance amongCandida spp. andAspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors for antifungal resistance is essential to retaining their clinical utility.Recent FindingsInvasive candidiasis is increasingly caused by non-albicans Candida species with reduced susceptibility to first-line antifungals, making empiric treatment decisions difficult. Echinocandin resistance inC. glabrata is increasing at some high-risk centers, and multi-drug-resistant isolates are increasingly encountered. Of large concern is the rapid and global emergence ofC. auris, a species associated with a high propensity for developing multi-drug resistance and nosocomial transmission. Azole resistance is now becoming more common inAspergillus isolates as well, with breakthrough infections occurring in patients previously managed with azoles antifungals. The appearance of azole-resistantAspergillus isolates in azole-na ïve patients is also concerning, given it is now accepted that this may be due to the use of non-human azole compounds in pesticides.SummaryDue to the climbing use of antifungals in both the clinical and agricultural sectors, the frequency of encounters with antifungal-resistant isolates will undoubtedly rise in parallel. Antifungal stewardship wi...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research

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Conclusion: Cladosporium can cause endogenous endophthalmitis and mimic toxoplasma retinochoroiditis. Vitreous biopsy can help in diagnosis in the absence of positive blood culture. Intravitreal voriconazole along with systemic voriconazole shows a good response. PMID: 31825695 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
In this study, we determined the antimicrobial activity of ten essential oils (EOs)—oregano, thyme, clove, arborvitae, cassia, lemongrass, melaleuca, eucalyptus, lavender, and clary sage—against drug-resistant microorganisms previously isolated from patients with skin infections. The essential oil compositions were determined using gas chromatography coupled to mass spectrometry (GC/MS). The assayed bacteria included Pseudomonas aeruginosa, Proteus vulgaris, Citrobacter koseri, and Klebsiella pneumoniae. Two drug-resistant yeasts (Candida albicans and Candida parapsilosis) were also involved in our surv...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study was designed to examine the prevalence of Candida albicans alcohol dehydrogenase 1 (CaADH1) gene in oral dysplasia as well as oral squamous cell carcinoma (OSCC) with and without lymph node metastasis (LNM) using reverse transcription polymerase chain reaction (RT-PCR) in order to determine its role in initiation, propagation and metastasis of oral dysplasia and carcinoma. Formalin-fixed parafin-embedded specimens were grouped into four groups: 7 control, 16 oral dysplasia, 16 OSCC without LNM and 15 OSCC with LNM. All specimens were examined by periodic acid Schiff (PAS) stain to detect Candida h...
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research
(Natural News) Lung moss (Lobaria pulmonaria) contains plant-based compounds with antibiotic and anti-fungal properties. A study from the Shandong University (SDU) tested their efficacy on drug-resistant Candida albicans to identify the most active molecules. The researchers received funding from the National Natural Science Foundation and the SDU’s Young Scholars Program. They published their findings in...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractSepsis remains a leading cause of mortality worldwide and is characterized by sustained inflammatory responses, reflected as changes in the expression profile of cytokines with time. The aim of the present study was to investigate the dynamic changes in complete blood count, serum chemistry, procalcitonin (PCT), tumor necrosis factor-alpha (TNF- α), and interleukin-6 (IL-6) inEscherichia coli,Staphylococcus aureus, andCandida albicans bacteremia. Study subjects were 32 healthy male Landrace-Large White pigs, aged 10 –15 weeks and of average weight 19 ± 2 kg. Bacteremia was induced by continuous i...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Gamal A. Mohamed, Sabrin R.M. Ibrahim, Hani Z. AsfourAbstractTwo new diaryl ether derivatives [aspergillethers A (4) and B (5)] and five known metabolites [(22E,24R)-stigmasta-5,7,22-trien-3-β-ol (1), stigmasta-4,6,8(14),22-tetraen-3-one (2), orcinol (3), and butyrolactones I (6) and VI (7)] were separated from the endophytic fungus Aspergillus versicolor (Aspergillaceae) isolated from the roots of Pulicaria crispa Forssk (Asteraceae) growing in Saudi Arabia. The structures of these compounds were determined by various spectral techniqu...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
There are only few drugs available to treat fungal infections, and the lack of new antifungals, along with the emergence of drug-resistant strains, results in millions of deaths/year. An unconventional approach to fight microbial infection is to exploit nutritional vulnerabilities of microorganism metabolism. The metal gallium can disrupt iron metabolism in bacteria and cancer cells, but it has not been tested against fungal pathogens such as Aspergillus and Candida. Here, we investigate in vitro activity of gallium nitrate III [Ga(NO3)3] against these human pathogens, to reveal the gallium mechanism of action and understa...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
ConclusionsPMMA acrylic resin base material was superficially modified through the incorporation of carboxylic acid groups by using PAA and PIA coatings that reduced the adherence of C albicans biofilm by 90%.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Authors: Casagrande Pierantoni D, Bernardo M, Mallardo E, Carannante N, Attanasio V, Corte L, Roscini L, Di Fiore L, Tascini C, Cardinali G Abstract A correct, fast, reliable identification method is pivotal in nosocomial environments to guide treatment strategies, whereas misidentification might lead to treatment failure. For routine identifications the Vitek system and CHROMagar are widely used but not always reliable, especially now with an increasing number of new emerging fungal pathogens that need careful identification. Here we describe two cases of candidemia, due to Candida palmioleophila previously miside...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Publication date: Available online 9 December 2019Source: PolymerAuthor(s): O.I. Timaeva, N.A. Arkharova, A.S. Orekhov, V.V. Klechkovskaya, S.P. Mulakov, G.M. Kuz'micheva, I.I. PashkinAbstractComposite hydrogels in the poly-N-vinylpyrrolidone – RE(NO3)3 × xH2O system with RE = La, Gd, Yb were prepared in various forms (native, native dried in the air, dried in air and ground into powder). They were studied by methods of wide- and small-angle X-ray scattering, differential scanning calorimetry, scanning electron microscopy, and electron microprobe analysis. The composition of native PVP and PVP with powd...
Source: Polymer - Category: Chemistry Source Type: research
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