Role of environmental factors in the pathogenesis of Crohn ’s disease: a critical review
ConclusionWe review the current information on the causative factors and mechanisms of CD, including smoking, exercise, diet, animal protein, breastfeeding, history of childhood infection and vaccination, oral contraceptives, and antibiotics of CD. However, further studies are needed to understand knowledge gaps in the field of CD.
We present the case of a 39-year-old male treated with Etanercept and debut of inflammatory bowel disease 11 months later. A literature review of the possible relationship between the debut and the treatment with Etanercept is done. PMID: 31793319 [PubMed - as supplied by publisher]
Conditions: Intestinal Disorder; Inflammatory Bowel Diseases; Crohn Disease Intervention: Other: acupuncture Sponsors: Shanghai Institute of Acupuncture, Moxibustion and Meridian; Fudan University; Shanghai University of Traditional Chinese Medicine; Shanghai Jiao Tong University School of Medicine; Indiana University School of Medicine Recruiting
We report the case of a Nigerian child with JIA who developed CD following treatment for JIA. A 9-year-old male with JIA was referred to the pediatric gastroenterology unit of the Lagos University Teaching Hospital on the account of chronic diarrhea with occasional passage of bloody stools. He had been on prednisolone and methotrexate which had controlled the joint flares. Colonoscopy revealed extensive colitis, ulcers, abscesses, and ileocecal disease. Histology confirmed the CD. In view of the unavailability of the recommended treatment, namely biologics in the country and financial constraints; steroids; and sulfasalazi...
Deep remission, based on clinical remission and evidence of healing during endoscopic evaluation, are goals of medical treatments for Crohn ’s disease (CD). We investigated whether histologic healing is associated with outcomes of patients with CD ileitis.
ConclusionsIL-17 contributes to the pathogenesis of intestinal fibrosis, and anti-IL-17 therapy may weaken this effect by downregulating expression of profibrogenic cytokines and disturbing the MMP/TIMPs balance.
AbstractThe aim of this study was to evaluate rates of clinical remission, endoscopic remission, and mucosal healing after a 6-week treatment period with partial enteral nutrition (PEN) and to compare them to those obtained by standard exclusive enteral nutrition (EEN) treatment in children with active Crohn ’s disease (CD). Twenty-five patients with active CD (median age 13.6 years, range 3.6–18.0) were recruited to either PEN (n = 12) or EEN (n = 13) treatment groups. The PEN group received 75% of their dietary needs from a polymeric formula plus one meal per day from an anti-inflammatory diet (AID). Patients...
Drug therapies and the postoperative management of patients will be in the spotlight at the upcoming Advances in Inflammatory Bowel Diseases conference.Medscape Medical News
Conditions: Crohn Disease; Pediatric Crohns Disease Interventions: Drug: Azithromycin; Drug: Metronidazole; Other: Standard of Care Sponsors: University of North Carolina, Chapel Hill; Crohn's and Colitis Foundation; University of Amsterdam Not yet recruiting
Conclusions: The high prevalence of psychological disorders and malnutrition were found in IBD patients, and thereby negatively affect QoL. Disease activity was significantly associated with psychological disorders, risk of malnutrition and impaired QoL. And avoiding certain foods was related to risk of malnutrition. PMID: 31791216 [PubMed - as supplied by publisher]
Which endoscopic procedure best identifies neoplasia in patients with ulcerative colitis or Crohn disease?Alimentary Pharmacology &Therapeutics