Abnormal Activation of Myeloid Dendritic Cells in JORRP Patients and Associated with Disease Activity.

CONCLUSION: Our results demonstrate an abnormal TLR2 and TLR4 expression in mDCs may contribute to suppressive immune response to HPV6 or HPV11 infection and associated with disease activity in JORRP patients. PMID: 31726188 [PubMed - as supplied by publisher]
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research

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AbstractPurpose of ReviewPhotodynamic therapy is approved in the USA for curative treatment of microinvasive endobronchial non-small cell lung cancer and palliation of symptoms with obstructing endobronchial non-small cell lung cancer. New data support its use with positive margins after surgical resection. Emerging data suggest it is both safe and efficacious for use in the periphery with non-small cell lung cancer.Recent FindingsSeveral case series have demonstrated its utility with endobronchial disease from small cell lung cancer. Recent studies have examined its use with recurrent respiratory papillomatosis, adenoid c...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Recurrent respiratory papillomatosis (RRP) is a rare disease caused by the human papilloma virus (HPV) and characterized by recurrent growth of benign papillomas in the upper and lower respiratory tract. The aim of the study was to increase the effectiveness of RRP treatment using the wide spectrum of diagnostic and therapeutic bronchological methods. 29 patients aged from 18 to 72 years old with RRP were included. In three patients - the juvenile form of RRP was diagnosed, in the remaining- the adult. Flexible bronchoscopy with biopsy and histological examination with microscopic staining and immunohistochemistry (Ki67, p...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Publication date: Available online 18 November 2019Source: American Journal of OtolaryngologyAuthor(s): Vivian Narana Ribeiro El Achkar, Andressa Duarte, Román Carlos, Jorge Esquiche León, Alfredo Ribeiro-Silva, Shirley Shizue Nagata Pignatari, Estela KaminagakuraAbstractObjectiveTo characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale.Materials and methodsThe data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients wer...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: Available online 8 November 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Ashley P. O'Connell FersterThe use of lasers in laryngology has evolved over the last several decades. With improving optics, instrumentation, and applications for treatment, lasers are now routinely used during laryngeal surgery performed in both the operating room and clinic settings. A variety of laser types, including carbon dioxide (CO2), potassium-titanyl-phosphate (KTP), and pulsed-dye lasers, are used to treat an array of benign laryngeal lesions. Otolaryngologists can now consider the us...
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - Category: ENT & OMF Source Type: research
Vestibular papillomatosis refers to small bumps that can occur on the vulva. These bumps are not a sign of disease and are not contagious. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news
Publication date: Available online 26 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Adi Primov-Fever, Ory MadgarRecurrent laryngeal papillomatosis is a viral (human papillomavirus) disease that causes the growth of epithelial verrucous lesions. Patients with laryngeal papillomatosis undergo multiple surgeries due to the tendency of the lesions to reoccur and cause recurrent voice and breathing problems. The goal of the surgical treatment is to remove the lesions while protecting the delicate layered structure of the vocal folds in order to prevent scarring and permanent damage t...
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - Category: ENT & OMF Source Type: research
This article highlights the clinical presentations of these conditions in skin of color and briefly addresses pathophysiology and treatment modalities.
Source: Journal of Pediatric Health Care - Category: Pediatrics Authors: Tags: Pharmacology Continuing Education Source Type: research
Abstract Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therapy used when surgery cannot control disease recurrence. Numerous adjuvant therapies have been used to control RRP with some success, but none are curative. Current literature supports a polarization of the adaptive immune response to a TH 2-like or T-regulatory phenotype, driven by a complex i...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
CONCLUSION: AN should be considered as cutaneous sign either of malignancy or endocrinopathy and therefore requires further investigations. The existence of extensive lesions, pruritus, tripe palms syndrome, florid cutaneous papillomatosis or mucous lesions, associated to an AN is a sign of malignancy should be investigated urgently the early diagnosis of which can lead to a better prognosis. PMID: 31564378 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
ConclusionsSystemic bevacizumab appears to be a safe and well tolerated treatment option for patients with severe RRP. It demonstrates promising efficacy on symptoms including voice quality and improved breathing as well as decreased requirement for surgical therapy.Legal entity responsible for the studyThe author.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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