Neurocritical Care for Extracorporeal Membrane Oxygenation Patients

Conclusions: A large knowledge gap exists in our understanding and treatment of extracorporeal membrane oxygenation-related neurologic complications. A systematic and multidisciplinary approach is needed to reduce the prevalence of these complications and to better manage the neurologic sequelae of extracorporeal membrane oxygenation in a way that will improve patient outcomes.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research

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AbstractPurposeMalignant carotid body tumor (CBT) is a rare disorder with poor prognosis. In this article, we presented the clinical features and surgical management of malignant CBTs at our department, aiming to improve the outcome for treating such lesions.MethodsA retrospective analysis (2005 –2018) of CBT excisions at our institution was performed. About 195 patients with CBTs were identified, among which 11 patients with eleven malignant CBTs were identified and carefully reviewed. Data obtained included demographics, radiological details, intra-operative details, post-operative morb idity, and long-term outcome...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
AbstractThe initial clinical status after subarachnoid hemorrhage (SAH) is an important outcome predictor, but the mechanisms behind the early brain injury (EBI) remains incompletely understood. Elevated neurofilament levels in the cerebrospinal fluid at protracted stages after SAH are associated with poor outcome, but the potential association between plasma neurofilament (pNfL) levels during EBI, disease severity on admission, and poor outcome remains unaddressed. Plasma NfL (pNfL) was measured by single molecule array in 44 SAH patients on admission and 24  h after ictus, as well as in 44 controls. Disease severity...
Source: Translational Stroke Research - Category: Neurology Source Type: research
This study assessed the efficacy of a pro-thrombotic VTA targeting phosphatidylserine (PS) in a radiation-primed AVM animal model. The model AVM was surgically created in rats by anastomosis of the left external jugular vein to the adjacent common carotid artery. After 6  weeks, the AVM was irradiated (20 Gy) using gamma knife surgery (GKS). A PS-targeting VTA was created by conjugation of annexin V with human thrombin and administered intravenously 3 weeks post-GKS or sham. Unconjugated thrombin was used as a non-targeting control. AVM thrombosis and occlusion w as monitored 3 weeks later by angiograph...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with devastating consequences, including a high mortality rate and severe disabilities among survivors. Inflammation is induced following SAH,...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
ConclusionTraumatic dACA aneurysm is a rare complication of brain trauma. Delayed intracranial haemorrhage and the sudden deterioration of neurologic function were the typical characteristics in patients with traumatic dACA aneurysm. CTA is the first-line screening modality for patients who present with intracerebral haemorrhage in the corpus callosum after trauma, particularly for patients who are older, in a poorer or critical condition. When the aneurysm is located in the A4 segment or involves a small branch, surgical trapping is the preferred definitive therapy to prevent further growth and disastrous bleeding. Early ...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
In this study, the authors proposed that pretreatment systolic blood pressure is a simple predictor of symptomatic and asymptomatic hemorrhagic infarction (HI) post intravenous thrombolysis (IVT). To validate their finding, they have further compared the pretreatment systolic BP with Glucose Race Age Sex Pressure Stroke Severity (GRASPS) and Totaled Health Risks in Vascular Events (THRIVE) scores and suggested that pretreatment systolic BP is a better predictor of postthrombolysis hemorrhage, and proposed a cut off for 160 mm Hg.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Conclusions: The results of this study indicate that combination of CD19- and CD70-specific CAR T-cells may effectively target PCNSL and maintain disease-free survival without inducing CRS or CRES. Therefore, central nervous system lymphoma is not an absolute contraindication for dual-target CAR T-cell therapy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionIt was found that Onyx embolization is safe and represents a  good option for an initial treatment approach, in a sequential treatment strategy for pediatric ruptured brain AVMs. Younger age may not be an argument to deny Onyx embolization.
Source: Clinical Neuroradiology - Category: Neurology Source Type: research
ConclusionCognitive impairment and dementia affected almost one-third of patients, whether assessed pre or post ICH.
Source: Neurological Sciences - Category: Neurology Source Type: research
The use of artificial intelligence (AI) can significantly improve the interpretation...Read more on AuntMinnie.comRelated Reading: AI needs robust clinical evaluation in healthcare Deep-learning model characterizes PET/CT findings Can AI find brain hemorrhage as well as radiologists? AI tops recent imaging informatics highlights Video from SIIM 2019: Dr. Howard Chen on recent advances in imaging informatics
Source: Headlines - Category: Radiology Source Type: news
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