Prospective evaluation of 68Ga-DOTANOC positron emission tomography/computed tomography and 131I-meta-iodobenzylguanidine single-photon emission computed tomography/computed tomography in extra-adrenal paragangliomas, including uncommon primary sites and to define their diagnostic roles in current scenario
Aim To evaluate 68Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) and 131I-meta-iodobenzylguanidine single-photon emission computed tomography/computed tomography (131I-MIBG SPECT/CT) in patients with paragangliomas, including uncommon primaries. Methods Ninety patients were prospectively enrolled, and both scans were done within 2 weeks of each other. Lesions were grouped as Head/neck, abdominal, uncommon primary paraganglioma, and metastatic lesions. In most histopathology was used as reference standard. Results PET/CT had sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 97%, 94%, 99%,88%,97% respectively on patient wise analysis (90) and 98%, 94%, 99%, 85% and 97% respectively on lesion wise analysis (149). Comparison with MIBG SPECT/CT: Significant difference in sensitivities noted (PET/CT-98%, I-131 MIBG -39%) (P
A patient enrolled in a clinical trial (NCT02802969) with suspicion of chordoma underwent an [18F]FAZA PET/CT, a radiolabeled nitroimidazole analog of hypoxia PET imaging. The patient's images showed a different tumor profile compared to those observed in other hypoxic or nonhypoxic chordoma patients. The motivation for using [18F]FAZA pharmacokinetic imaging was to compare this profile with histologically confirmed cases of chordoma. Through visual imaging and quantification of blood and tumor time-activity curves, we excluded the hypothesis that it was a chordoma, diagnosing a paraganglioma.
Conditions: Adrenocortical Carcinoma; Pheochromocytoma; Paraganglioma Intervention: Biological: EO2401 Sponsor: Enterome Not yet recruiting
This study aimed to compare the differences in their clinical characteristics and cystoscopic features. Patients and Methods: Between April 2007 and September 2017, 14 patients with NPB (NPB group) were retrieved from 2 centers, and 42 patients with new-onset UCB (UCB group) were randomly retrieved. Demographic, symptomatic, imaging, and cystoscopic data of patients in both groups were collected and compared. Results: NPB group comprised 7 males and 7 females, with a mean age of 43.1 ± 13.6 years. Compared with the UCB group, patients in the NPB group were significantly younger (p
Introduction - Carotid body tumors (also called paragangliomas)developed within the adventitia of the medial aspect of the carotid bifurcation. These neoplasms originate in the neural crest. Normal carotid body has 6x3 dimensions, but simultaneusly it has the body's largest blood flow per gram of tissue. Parasympathetic paragangiomas are rare, with the prevalance of 0,6 per million inhabitants, although at high altitudes regions of Peru and Mexico the prevalance rises to 1 per 30,000 inhabitants.
This study analyzed the predictive factors for perioperative complications in patients with NP.
Introduction: The aim of this study is to evaluate the outcomes of treatment of neck paragangliomas (NPs), before and after a multidisciplinary approach including preoperative Succinate Dehydrogenase (SDH) gene mutation analysis, genetic counseling and preoperative adjunctive endovascular procedures (PAEPs).
ConclusionsA delay in diagnosis or lack of a diagnosis in pheochromocytoma and paraganglioma may increase the perioperative morbidity and mortality risk due to excess catecholamine secretion. Therefore, routine pheochromocytoma and paraganglioma screening preoperatively in patients with neurofibromatosis type 1 is very important.
Purpose of review Although the majority of pheochromocytoma and paraganglioma are benign, 15–17% develop metastatic disease, being present at the initial diagnosis in about 11–31% of cases. The natural course of metastasized disease is highly heterogeneous, with an overall 5-year survival rate varying between 40% and 85%. For individual patients, overall survival, progression-free survival, and clinical outcome are difficult to predict. Management of metastasized pheochromocytoma and paraganglioma is challenging. Currently available therapeutic options are surgical debulking, treatment with radiopharmaceutica...
AbstractGastrointestinal stromal tumors (GISTs) are increasingly recognized as having diverse biology. With the development of tyrosine kinase inhibitors molecularly matched to oncogenicKIT andPDGFRA mutations, GISTs have become a quintessential model for precision oncology. However, about 5 –10% of GIST lack these driver mutations and are deficient in succinate dehydrogenase (SDH), an enzyme that converts succinate to fumarate. SDH deficiency leads to accumulation of succinate, an oncometabolite that promotes tumorigenesis. SDH-deficient GISTs are clinically unique in that they gener ally affect younger patients and...
We report a 39-year-old man with a giant high-risk esophageal paraganglioma who underwent a hybrid minimally invasive 3-hole esophagectomy.