Association between Apolipoprotein E Gene Polymorphism and Alzheimer's Disease in an Iranian Population: A Meta-Analysis

AbstractThe development of Alzheimer's disease (AD) has been strongly linked to the apolipoprotein E (APOE) polymorphism. A number studies have reported that theAPOEε4 allele is a genetic risk factor for developing AD, whereas theAPOEε2 andAPOEε3 alleles are considered to be neutral or even protective; however, there are conflicting data about these relationships in certain ethnic populations. Several meta-analyses have been performed to reduce the heterogeneity of results from different studies and estimate the real association in speci fic ethnicities. The aim of this study was to investigate the association between theAPOE polymorphism and AD in an Iranian population. Our results showed a higher incidence of AD among individuals carrying theAPOEε4 allele (OR = 4.81, 95% CI: 3.28–7.05), more notably in those with theAPOEε4/e4 genotype (OR = 7.47, 95% CI: 2.35–23.73), while carrying theAPOEε3 allele was demonstrated to have a protective effect (OR = 0.40, 95% CI: 0.30–0.54). The association between theAPOEε2 allele and AD was not statically significant. However, further studies focusing on other parameters such as age, sex and environmental conditions are needed to reveal the true association between theAPOE polymorphism and AD.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research

Related Links:

Condition:   Mild Cognitive Impairment Interventions:   Drug: T-817MA;   Drug: Placebo Sponsor:   FUJIFILM Toyama Chemical Co., Ltd. Recruiting
Source: - Category: Research Source Type: clinical trials
Irene Taylor Brodsky's doc reveals her deaf son's triumph and her deaf dad's Alzheimer's challenges ... "If you told my dad 50 years ago that there would be this tool that would allow him to hear, ...
Source: News - Category: American Health Source Type: news
In conclusion, DZSM capsules protected against cognitive defects of AD through scutellarin-mediated acceleration of Aβ aggregation into fibrils or protofibrils and reduction of soluble Aβ oligomers, thus suggesting potential clinical applications of DZSM capsules and scutellarin in the treatment of AD. PMID: 31810113 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Abstract Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis. Recent advances in research throw more lights of its beneficial role towards Alzheimer's disease (AD), including promoting β-amyloid (Aβ) clearance, as well as inhibiting Aβ production in the triple-transgenic mouse model of Alzheimer's disease (3×Tg AD). However, it remains unclarified if berberine has an effect on tau pathology. According to our study, berberine did not only significantly improve 3×Tg AD mice's spatial learning capacity and memory retentions, but also attenuated the hyperphosphory...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
ConclusionThe HGT carried out with the ALZENTIA system proved to be a reliable screening test to identify individuals with MCI from an aging cohort.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
The bacteria in our bodies affect our minds. Cell biologist Sim Singhrao explains how improved oral hygiene, diet and exercise can stave off dementia
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Longtime "Sunday Morning" viewers will recognize Eugenia Zukerman, the internationally-acclaimed flutist, who for more than 20 years covered the arts for this broadcast. But now, Zukerman is opening up to Rita Braver about her battle with Alzheimer's, and how music, writing and humor are helping her cope, as she describes in her book, "Like Falling Through a Cloud: A Lyrical Memoir of Coping With Forgetfulness, Confusion, and a Dreaded Diagnosis."
Source: Health News: - Category: Consumer Health News Source Type: news
Photo credit Aaron Burden Dear Carol: I dread Christmas. My husband died last summer and this is my first Christmas without him. He'd been sick with cancer and then Alzheimer's, and part of me is happy that he was finally able to let go. Other times, I'd give anything for him to be here, which is actually selfish considering his obvious misery. I have wonderful children and friends and I have a church family where I feel I belong. Still, I sometimes feel angry that my husband left me alone. It's a confusing holiday season for me. Why can't I remain grateful that my husband isn't suffering? -Grace Continue reading on Inforu...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
The acclaimed flutist, broadcast journalist and author opens up about her diagnosis, and how music, writing and finding joy in life are helping her cope with a fading memory
Source: Health News: - Category: Consumer Health News Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Alzheimer's | Brain | Environmental Health | Genetics | Iran Health | Neurology | Neuroscience | Study