Molecular mechanism of azithromycin resistance among typhoidal Salmonella stains in Bangladesh identified through passive pediatric surveillance

ConclusionsThis report confirms 12 azithromycin-resistantSalmonella Typhi strains and one Paratyphi A strain. The molecular basis of this resistance is one mutation in the AcrB protein at position 717. This is the first report demonstrating the impact of this non-synonymous mutation in conferring macrolide resistance in a clinical setting. With increasing azithromycin use, strains with R717 mutations may spread and be acquired by XDR strains. An azithromycin-resistant XDR strain would shift enteric fever treatment from outpatient departments, where patients are currently treated with oral azithromycin, to inpatient departments to be treated with injectable antibiotics like carbapenems, thereby further burdening already struggling health systems in endemic regions. Moreover, with the dearth of novel antimicrobials in the horizon, we risk losing our primary defense against widespread mortality from typhoid. In addition to rolling out the WHO prequalified typhoid conjugate vaccine in endemic areas to decrease the risk of pan-resistantSalmonella Typhi strains, it is also imperative to implement antimicrobial stewardship and water sanitation and hygiene intervention to decrease the overall burden of enteric fever.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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Conclusion: The prevalence of Abnormal Liver function tests in patients of COVID-19 is 59.04%. Abnormal liver functions were more in males. The average stay in hospital for COVID-19 patients with abnormal LFTs was longer than those with normal LFTs. PMID: 32738845 [PubMed - as supplied by publisher]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: This hospital-based registry shows that mildly symptomatic or asymptomatic young covid-19 patients have excellent prognosis. PMID: 32738843 [PubMed - as supplied by publisher]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: The venom of P. bundokalbo spider, an endemic tarantula species in the Philippines, contains components that were able to induce either apoptosis or necrosis in A549 cells.
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
Conclusions: Proteins are very effectively associated with liposomes via a GPI -anchor to form proteoliposome particles and these are useful for a variety of applications including vaccines and antibody-mediated targeting of liposomes. Importantly, the CHO-cell and GPI-tagged produced PfRH5 elicited invasion-blocking antibodies qualitatively comparable to other approaches.
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
Publication date: Available online 2 August 2020Source: Fish &Shellfish ImmunologyAuthor(s): Zhao Zhao, Yan Xiong, Chen Zhang, Yi-Jun Jia, De-Kui Qiu, Gao-Xue Wang, Bin Zhu
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
The American Institute of Biological Sciences joined a coalition of 90 scientific, academic, and medical groups to express support for the continued use of human fetal tissue in biomedical research. In a July 28, 2020, letter to the National Institutes of Health (NIH) Human Fetal Tissue Research Ethics Advisory Board, the groups argued, in part: “The long-standing existing review process for fetal tissue research ensures that research using fetal tissue is scientifically meritorious, legal, and ethically sound. The legal framework for this research prohibits people from profiting from acquiring, receiving, or transf...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
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Source: Public Policy Reports - Category: Biology Authors: Source Type: news
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news US news UK news Science Infectious diseases Source Type: news
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Russia Coronavirus outbreak Science Europe World news Infectious diseases Source Type: news
The Pennsylvania Department of Health is hiring 1,000 additional contract tracers to bolster the state ’s efforts to contain coronavirus outbreaks by quickly notifying people who might have been exposed according to WPXI. The Health Department announced a $23 million, federally funded contract with Atlanta-based staffing agency Insight Global to recruit, hire and train the new workers, who will jo in the state’s existing contact-tracing force of more than 650 WPXI reports. The new jobs include…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
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