Synthesis and cytotoxicity evaluation of panaxadiol derivatives.

In this study, 13 Panaxadiol (PD) derivatives were synthesized via reactions with aromatic compounds and amino acids. Following this, the cytotoxicity of these compounds was evaluated against four cancer cell lines (human hepatoma cell HepG-2, human lung cancer cell A549, human breast cancer cell MCF-7, and human colon cancer cell HCT-116) and one normal cell line (human gastric epithelial cell line-GES- 1). The results showed that Compounds 3, 12, and 13 showed significant inhibition of cellular proliferation against cancer cells compared with PD, and Compound 12 had the lowest IC50 value for A549 (IC50 = 18.91 ± 1.03 μM). For MCF-7 cells, most compounds exhibited good inhibition of cellular proliferation, and Compound 13 showed the strongest inhibitory effect (IC50 = 8.62 ± 0.23 μM), which significantly increased the cytotoxicity of PD and was stronger than the positive control (Mitomycin). For normal cells, all compounds exhibited low or no toxic effects; thus, these compounds can be used to develop novel anti-proliferative agents. PMID: 31725193 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research