Changes to Liver Structure and Energy Metabolism During Cold Storage of Transplanted Liver in Mice.

CONCLUSIONS: Mouse livers showed progressive damage to structure and function during cold storage, with mitochondrial damage perhaps showing the earliest damage. PMID: 31724923 [PubMed - as supplied by publisher]
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research

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ConclusionsAttempting to meet the demand for livers, transplant centers are increasingly turning to living donor liver transplantation, protocols such as HCV-positive to HCV-negative transplants, and machine perfusion of marginal organs.
Source: Abdominal Imaging - Category: Radiology Source Type: research
A Swiss collaboration of clinical researchers from University Hospital Zurich, ETH Zurich, Wyss Zurich, and the University of Zurich has created a machine that can keep human livers alive for up to a week. For comparison, current methods of perfusion...
Source: Medgadget - Category: Medical Devices Authors: Tags: Surgery Source Type: blogs
CONCLUSIONS Splitting the liver under machine perfusion preservation may help restore the function and reduce ischemia-reperfusion injury. PMID: 31932575 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
In conclusion, we established effective, robust and fast decellularization protocols for both porcine and human livers. With this protocol the duration of decellularization for whole-organ human livers has been shortened considerably. The increased pressure and flow did not damage the ECM, as major ECM components remained intact. PMID: 31923991 [PubMed - in process]
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
AbstractContrast-enhanced ultrasound (CEUS) is gaining ever-increasing acceptance in the preoperative and postoperative evaluation of liver-transplanted patients. While indications are still a matter of research, CEUS is used in tertiary centers to supplement ultrasound (US) and Color Doppler US examination, with the potential of providing a comprehensive first-line ultrasound-based diagnosis. Alternatively, CEUS is used as a problem-solving tool when previous cross-sectional or US imaging was inconclusive, especially in assessing hepatocellular carcinoma, parenchymal perfusion abnormalities, the vascular status, and even ...
Source: Abdominal Imaging - Category: Radiology Source Type: research
ConclusionsThe described procedure is feasible only for surgeons with a transplantation background. The study showed that this translational approach enhances the surgeon ’s ability to perform the intervention systematically in a shorter time and with a good outcome.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: In Brief Source Type: research
This study aimed to evaluate whether blocking the TSP1-CD47 signaling pathway could attenuate the acute rejection after liver transplantation. An allogeneic mouse orthotopic liver transplantation model (Balb/c→C3H) with prolonged cold ischemic phase was used to induce severe IRI and lethal acute rejection. CD47mAb or isotype matched-control IgG2a was administered to donor liver during graft perfusion. Recipients were sacrificed at 1d, 3d, 5d and 7d after reperfusion. Blood samples were collected to evaluate serum alanine aminotransferase, total bilirubin, HMGB-1,TNF-α, IL-2 and INF-γ level. Flow cytometric...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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