Pediatric Pure Red Cell Aplasia Caused by Tacrolimus After Living-Donor Liver Transplant.
Pediatric Pure Red Cell Aplasia Caused by Tacrolimus After Living-Donor Liver Transplant.
Exp Clin Transplant. 2019 Nov 13;:
Authors: Watanabe S, Sakamoto R, Yamamoto H, Imaya M, Yamashita T, Anann T, Nakamura K
Abstract
Pure red cell aplasia is a relatively rare disease characterized by selective suppression of erythroid precursors in the bone marrow. This disease can also develop secondary to several other diseases and as a side effect of certain drugs. Tacrolimus, a potent immunosuppressant, is widely used in organ transplant. Several cases of pure red cell aplasia due to tacrolimus administration in organ transplant recipients have been reported.Here, we report a case of reversible pure red cell aplasia that developed during tacrolimus therapy following living-donor liver transplant. The patient, a 1-year-old girl diagnosed with progressive familial intrahepatic cholestasis type II, underwent living-donor liver transplant when she was 10 months old. She was started on 3 immunosuppressants posttransplant: tacrolimus (0.1 mg/kg/day twice daily), mycophenolate mofetil, and prednisolone (0.2 mg/kg/day). One year after transplant, she developed severe progressive anemia. Her hemoglobin concentration was extremely low (5.4 g/dL). A bone marrow biopsy revealed severe hypoplasia of the erythroblasts with no abnormality of other myelocytes. These findings were suggestive of pure red cell aplasia; we suspected that tacrolimus had caused th...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Watanabe S, Sakamoto R, Yamamoto H, Imaya M, Yamashita T, Anann T, Nakamura K Tags: Exp Clin Transplant Source Type: research
More News: Anemia | Bone Marrow Aspiration and Biopsy | Cholestasis | Girls | Liver | Liver Transplant | Middle East Health | Obstetric Cholestasis | Pediatrics | Prednisolone | Prograf | Rare Diseases | Restasis | Tacrolimus | Transplant Surgery | Transplants | Urology & Nephrology