prevalence of functional dyspepsia symptoms in patients with asthma.
[PREVALENCE OF FUNCTIONAL DYSPEPSIA SYMPTOMS IN PATIENTS WITH ASTHMA]. Arerugi. 2019;68(9):1132-1140 Authors: Tomyo F, Sugimoto N, Toyota H, Ito A, Ujino M, Sakasegawa H, Kobayashi K, Koizumi Y, Miyoshi S, Kuramochi M, Yamaguchi M, Yamamoto T, Nagase H Abstract BACKGROUND: Gastroesophageal reflux disease (GERD) is a common comorbidity among patients with asthma. In addition, functional dyspepsia (FD) is characterized by upper abdominal symptoms without organic disease manifestations. However, the prevalence of FD among patients with asthma remains uninvestigated; therefore, herein, we investigated the prevalence of dyspepsia symptoms in these patients. METHODS: We recruited 156 patients with asthma from the outpatient clinic of Teikyo University Hospital and investigated the prevalence of dyspepsia symptoms using the modified Frequency Scale for the Symptoms of GERD. Further, the relationship between dyspepsia symptoms and clinical background of asthma was also investigated. RESULTS: Certain digestive organ symptoms were exhibited by 83% of patients with asthma, dyspepsia symptoms by 44%, and reflux symptoms by 26%. The dyspepsia-dominant group showed significantly higher female ratio and numerically lower %FEV1 than the asymptomatic group. In the group with dyspepsia score>5 points, the ratio of patients undergoing step 4 asthma treatment and the ratio of those using long-acting muscarinic receptor antagonist were higher than those in the g...
Publication date: Available online 24 September 2020Source: Chinese Chemical LettersAuthor(s): Wenbo Li, Yucen Li, Wei Zhang, Difeng Yin, Ya Cheng, Wei Chu, Ming Hu
Publication date: Available online 24 September 2020Source: Chinese Chemical LettersAuthor(s): Xiaofeng Tan, Jun Qin, Yan Li, Yuting Zeng, Jindi Gong, Gengxiu Zheng, Feng Feng, He Li
Environ. Sci.: Processes Impacts, 2020, Accepted Manuscript DOI: 10.1039/D0EM00311E, PaperElijah G Schnitzler, Tengyu Liu, Rachel Hems, Jonathan Abbatt The climate forcing of light-absorbing organic aerosol, or brown carbon (BrC), emitted from biomass burning may be significant but is currently poorly constrained, in part due to evolution during its... The content of this RSS Feed (c) The Royal Society of Chemistry
Publication date: Available online 24 September 2020Source: The Lancet Respiratory MedicineAuthor(s): Christopher E Brightling, Mina Gaga, Hiromasa Inoue, Jing Li, Jorge Maspero, Sally Wenzel, Samopriyo Maitra, David Lawrence, Florian Brockhaus, Thomas Lehmann, Caterina Brindicci, Barbara Knorr, Eugene R Bleecker
Publication date: Available online 24 September 2020Source: The Lancet Respiratory MedicineAuthor(s): Anna Schultze, Alex J Walker, Brian MacKenna, Caroline E Morton, Krishnan Bhaskaran, Jeremy P Brown, Christopher T Rentsch, Elizabeth Williamson, Henry Drysdale, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen I McDonald, Laurie Tomlinson
Conclusions: Successful treatment of GER-associated cough may be associated with the attenuation of neurogenic and neutrophilic inflammation. PMID: 31303089 [PubMed - as supplied by publisher]
Acid-suppressive medications, such as H2-receptor antagonists (H2RA) and proton pump inhibitors (PPI), are the main treatment options for dyspepsia and gastroesophageal reflux disease. These are common problems in pregnancy.1 Recently, concerns have been raised that prenatal exposure to these medications may increase the risk of allergic disease in the offspring.1 Dehlink et al1 were the first to report these associations, proposing that use of acid-suppressive medications in pregnancy may increase the risk of allergic disease in the offspring through interference with maternal digestion of labile antigens, ther...
Conclusion Chronic rhinosinusitis was diagnosed in more than 40% of children with dyspepsia. The odds of CRS being present in children diagnosed to have GERD increases significantly as demonstrated in this study.
We have previously suggested that oesophageal dysfunction may underlie a number of otherwise unexplained respiratory symptoms particularly chronic cough. However on conventional testing of oesophageal function using pH and impedance techniques few patients are abnormal. We have compared patients with unexplained respiratory symptoms with a control group with dyspepsia and heartburn using High Resolution Oesophageal Manometry.121 patients were studied, 61 with respiratory complaints and 60 with primarily gastrointestinal symptoms. Respiratory patients consisted of 38 females, combined mean age of 56, range (18 – 81) a...
Conclusion: Daytime phlegm and losing the sense of smell suggest that eosinophilic airway inflammation persists, despite anti-inflammatory therapy, in patients with asthma. Although rhinitis and GERD made the subjective symptoms of asthma worse, they did not seem to enhance eosinophilic airway inflammation. Keywords: asthma symptoms, FeNO, rhinosinusitis, GERD, dyspepsia