Optimization the formulation parameters in preparation of α-tocopherol nanodispersions using low-energy solvent displacement technique.

Optimization the formulation parameters in preparation of α-tocopherol nanodispersions using low-energy solvent displacement technique. Int J Vitam Nutr Res. 2019 Nov 14;:1-12 Authors: Jaberi N, Anarjan N, Jafarizadeh-Malmiri H Abstract α-Tocopherol is the main compound of vitamin E with great antioxidant activity. However, like other functional lipid bioactive compounds, it suffers from low bioavailability due to its low water solubility and liable chemical structure. A bottom-up procedure based on a solvent-displacement method was constructed for fabrication of α-tocopherol nanodispersions using response surface methodology (RSM). The effects of main formulation parameters, namely, weight ratio of emulsifier to α-tocopherol and volumetric percent of acetone to water on the average particle size (nm), polydispersity index, concentration of α-tocopherol loss (% w/w) and turbidity of the nanodispersions were evaluated and optimized to gain the most desirable nanodispersions (least particle size, polydispersity index, turbidity and highest α-tocopherol concentrations). Second order regression equations, holding quite high coefficients of determination (R2 and adjusted R2 > 0.882), were significantly (p-value < 0.05) fitted for predicting the α-tocopherol nanodispersion characteristics variations as functions of studied formulation parameters. A multiple optimization analysis offered 6.5 and 10% for weight ratio of Twe...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research