Teva to resume production of child cancer drug as shortage persists

Teva Pharmaceuticals announced that it will resume production of childhood cancer drug vincristine after a recent shortage.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news

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(Wellcome Trust Sanger Institute) A fundamental change in our understanding of the childhood kidney cancer Wilms' tumor is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators. By comparing genome sequences from normal kidney tissue and tumors, the team identified patches of normal-looking kidney tissue that in fact carried DNA changes that cause Wilms' tumor.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissues that preceded tumor development. These clonal expansions were defined by somatic mutations shared between tumor and normal tissues but absent from blood cells. We also found hyper...
Source: ScienceNOW - Category: Science Authors: Tags: Development, Medicine, Diseases reports Source Type: news
AbstractMinimally invasive surgery (MIS) to resect primary and metastatic pediatric embryonal tumors offers the potential for reduced postoperative morbidity with smaller wounds, less pain, fewer surgical site infections, decreased blood loss, shorter hospital stays, and less disruption to treatment regimens. However, significant controversy surrounds the question of whether a high-fidelity oncologic resection of childhood embryonal tumors with gross total resection, negative margins, and appropriate lymph node sampling can be achieved through MIS. This review outlines the diverse applications of MIS to treat definitively ...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
AbstractRecent studies suggest abnormal microRNA (miRNA) expression may have potential prognostic value in childhood acute lymphoblastic leukemia (ALL). In this systematic review, we searched different databases (PubMed, ASH, ASCO, and SIOP) for studies published from 2008 to 2018 that evaluated the prognostic impact of miRNAs in childhood ALL. We also used DIANA-miRPath v3.0 to further characterize the functional role of the significant prognostic miRNAs identified in our systematic review. Here we evaluate 15 studies with a total of 38 different miRNAs and 1545 children with B-cell ALL (B-ALL) or T-cell ALL (T-ALL) recru...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
Women who use permanent hair dye and chemical hair straighteners have a higher...Read more on AuntMinnie.comRelated Reading: High-risk women should start breast screening earlier Childhood radiotherapy, chemo boost breast cancer risk Black women still at higher risk of breast cancer death Young women at risk of breast cancer need screening DDT exposure tied to breast cancer risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
No abstract available
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
udevan Hepatoblastoma is the most common childhood liver malignancy. The management of hepatoblastoma requires multidisciplinary efforts. The five-year overall survival is approximately 80% in developed countries. Surgery remains the mainstay of treatment for hepatoblastoma, and meticulous techniques must be employed to ensure safe and effective local control surgeries. Additionally, there have been several advances from both pediatric and adult literature in the way liver tumor surgery is performed. In this review, we highlight important aspects of liver surgery for hepatoblastoma, the management of metastatic disease...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
AbstractMatrix metalloproteinases (MMPs) play a major role in extracellular matrix remodeling and are involved in tumor cell invasion. Cancers such as childhood leukemia are characterized by their capacity to infiltrate different organs. MMP production by leukemic cells may indicate a leukemic subtype or subpopulation with a more invasive phenotype. Therefore, clarifying the action mechanisms of MMPs as prognostic predictors or MMP targeting as a therapeutic strategy is necessary. MMP-targeting drugs have been developed for the treatment of hematological malignancies. In this review, we highlight current advances in unders...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
This article gives an overview o f the recent advances in the diagnostic/prognostic potential of miRNAs in a selection of pediatric CNS tumors: medulloblastoma, ependymoma, pilocytic astrocytoma, glioblastoma, diffuse intrinsic pontine glioma, atypical teratoid/rhabdoid tumors, and choroid plexus tumors.
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
on LM Abstract Quantification of radiation dose to normal tissue during radiotherapy is critical for assessing risk for radiotherapy-related late effects, including subsequent neoplasms (SNs). Case-control studies of SNs typically reconstruct absorbed radiation dose to the specific SN location using individual treatment parameters. A simplified method estimates the maximum prescribed target dose to the body region in which the SN arises. We compared doses and risk estimates from these methods using data from case-control studies of subsequent brain tumors (64 cases, 244 controls) and breast cancer (94 cases, 358 c...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
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