Degraded Fucoidan Fractions and β-1,3-Glucan Sulfates Inhibit CXCL12-induced Erk1/2 Activation and Chemotaxis in Burkitt Lymphoma Cells.

In conclusion, degradation of fucoidans to obtain biopharmaceutically more favorable Mw is possible without impairing their activities targeting CXCL12. Moreover, the β-1,3-glucan sulfates should also be considered as promising candidates for further development. PMID: 31726164 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research