Degraded Fucoidan Fractions and β-1,3-Glucan Sulfates Inhibit CXCL12-induced Erk1/2 Activation and Chemotaxis in Burkitt Lymphoma Cells.
In conclusion, degradation of fucoidans to obtain biopharmaceutically more favorable Mw is possible without impairing their activities targeting CXCL12. Moreover, the β-1,3-glucan sulfates should also be considered as promising candidates for further development.
PMID: 31726164 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Techel I, Lahrsen E, Alban S Tags: Int J Biol Macromol Source Type: research