Mild Zika infection in fetuses may cause brain abnormalities in young despite no symptoms

(University of Saskatchewan) Using a relevant animal model (pigs), University of Saskatchewan researchers have shown that mild Zika virus infection in fetuses can cause abnormal brain development in apparently healthy young animals. The study, published Nov. 14, 2019 in PLOS Pathogens, provides new insights into the potential outcomes of Zika virus infection and could point to new prevention and treatment strategies to alleviate the long-term effects of Zika virus infection.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Viruses such as human cytomegalovirus, rubella, varicella-zoster and West Nile have been reported to cause birth defects similar to Zika virus (ZIKV), and some of them have also been associated with long-term neurological impacts [1 –3]. Other clinically relevant neurotropic arboviruses include Flaviviruses (e.g., St. Louis encephalitis virus, and Japanese encephalitis virus), Bunyaviruses (e.g., La Crosse virus and California encephalitis virus) and New World Alphaviruses (e.g., Eastern, Western, and Venezuelan equine enceph alitis viruses) [4], It is also important to note that some viruses, like human immunodefici...
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
This study aimed to investigate the presence of Zika, Dengue and Chikungunya viruses in Ae. aegypti and Ae. albopictus from the municipalities of Alto Alegre, Caxias, Codó, and São Mateus do Maranhão, located in the state of Maranhão, Northeast Brazil. The mosquitoes were collected with a mechanical aspirator, identified, triturated, and then submitted to RNA extraction and RT-qPCR. The positive samples were confirmed by virus isolation and genome sequencing. Three hundred and forty-eight Ae. aegypti (176 males and 172 females) and 12 Ae. albopictus (eight males and four females)...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Conclusions: As seemingly benign viruses could turn deadly (e.g., Zika flavivirus) and EqHV happens to have infected a significant proportion of the world’s horse herds, EqHV infectious cycle should be further clarified.
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Condition:   Zika Virus Intervention:   Sponsors:   RTI International;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   University of North Carolina, Chapel Hill;   Sustainable Sciences Institute (Managua, Nicaragua);   Ministry of Health Nicaragua Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions/SignificanceOur results shed insights into the role ofompA gene in host-microbe interactions inAe.aegypti and confirm that CRISPR/Cas9 gene editing can be employed for genetic manipulation of non-model gut microbes. The ability to use this technology for site-specific integration of genes into the symbiont will facilitate the development of paratransgenic control strategies to interfere with arboviral pathogens such Chikungunya, dengue, Zika and Yellow fever viruses transmitted byAedes mosquitoes.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Developments in genetic engineering have allowed researchers and clinicians to begin harnessing viruses to target and kill cancer cells, either through direct lysis or through recruitment of antiviral immune responses. Two powerful viruses in the fight against cancer are the single-stranded RNA viruses vesicular stomatitis virus and Zika virus. Here, we describe methods to propagate and titer these two viruses. We also describe a simple cell-killing assay to begin testing modified viruses for increased potential killing of glioblastoma cells. PMID: 31776931 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Zika virus outbreaks have been explosive and unpredictable and have led to significant adverse health effects —as well as considerable public anxiety. Significant scientific work has resulted in multiple candidate vaccines that are now undergoing further clinical development, with several vaccines now in phase 2 clinical trials. In this review, we survey current vaccine efforts, preclinical and clinical r esults, and ethical and other concerns that directly bear on vaccine development. It is clear that the world needs safe and effective vaccines to protect against Zika virus infection.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Thematic review on vaccines Source Type: research
Publication date: Available online 28 November 2019Source: Antiviral ResearchAuthor(s): Diana Montes-Grajales, Henry Puerta-Guardo, Diego A. Espinosa, Eva Harris, William Caicedo-Torres, Jesus Olivero-Verbel, Esperanza Martínez-RomeroAbstractArboviral diseases caused by dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses represent a major public health problem worldwide, especially in tropical areas where millions of infections occur every year. The aim of this research was to identify candidate molecules for the treatment of these diseases among the drugs currently available in the market, through in silico ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 29 November 2019Source: Journal of Molecular BiologyAuthor(s): Pranav M. Khade, Ambuj Kumar, Robert L. JerniganAbstractThe functioning of proteins requires highly specific dynamics, which depend critically on the details of how amino acids are packed. Hinge motions are the most common type of large motion, typified by the opening and closing of enzymes around their substrates. The packing and geometries of residues are characterized here by graph theory. This characterization is sufficient to enable reliable hinge predictions from a single static structure, and notably, this can be from e...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
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