Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice

ConclusionsOur study constitutes the first functional study ofPtpn22 in B cells in NOD mice. Our findings suggest thatPtpn22 variation contributes to T1D by modifying the B cell compartment and support a gain-of-function for thePTPN22 disease variant.
Source: Endocrine - Category: Endocrinology Source Type: research