Effect of iDanggui Sinii Decoction on the Behaviour and Dorsal Root Ganglion TRP Channel of Neuropathic Pain in CCI Rats
D. Zhang, D. Chen, Shengsuo Ma, Wenyan Bian, F. Xie, Meina Huang, Haoming Lin, Qianxing Zhan and G. Zhao*
Condition: Pain, Neuropathic Interventions: Procedure: Stellate ganglion block; Procedure: Sham Stellate ganglion block Sponsors: Tanta University; Mohamad Gamal Elmawy, M.D Not yet recruiting
Discussion: High-voltage PRF of dorsal root ganglion delivered through multifunctional electrode provided significant pain relief and may be considered a valuable treatment in chronic lumbosacral radicular pain with neuropathic features.
A 33-year-old woman presented with bilateral dorsal wrist masses associated with pain and limited range of motion. On initial presentation, the masses were believed to be ganglion cysts and the patient opted for observation. Three years later, she was found to have a chest wall mass diagnosed by biopsy to be a neurofibroma. When she later returned to seek treatment for her wrist masses, magnetic resonance imaging demonstrated posterior interosseous nerve (PIN) neurofibromas. Dorsal wrist masses situated over the scapholunate interval are commonly attributed to ganglion cysts.
In conclusion, the present study determined that the activation of BDNF/p75NTR/mTOR signaling may participate in nociceptive transmission in CIBP, suggesting a novel mechanism and potential therapeutic target for CIBP treatment and management. PMID: 31777542 [PubMed]
Publication date: Available online 27 November 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Yoshizo Matsuka, Shaista Afroz, Junhel C. Dalanon, Takuma Iwasa, Arief Waskitho, Masamitsu OshimaAbstractNeuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotrans...
Publication date: Available online 20 November 2019Source: Life SciencesAuthor(s): Zhen-zhen Chen, Xin GongAbstractAimsOur study was designed to explore the function and mechanism of Tanshinone IIA in alleviating pain syndrome caused by endometriosis (EMs).Main methodsFemale Sprague-Dawley rats went through autotransplantation operation to establish EMs model. The rats were randomly divided into five groups: sham, model, positive, Tanshinone IIA (L) (3 mg/kg/d) and Tanshinone IIA (H) (12 mg/kg/d) group. Volume of ectopic endometrium was measured after 21 days of continuous administration. Serum estradiol (E2) was det...
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of local anesthetic sodium channel blockers like QX-314, this cationic compound inhibited N-type calcium channels more effectively with extracellular than intracellular application. Surprisingly, the compound is also a highly effective sodium channel inhibitor when applied extracellularly, producing more potent inhibition than lidocaine or bupivacaine. The charged inhibitor produced...
CONCLUSIONS: The sequential application of these three surgical procedures succeeded in reversing the serious situation of chronic CR refractory to an episodic CR in 93% of patients with acceptable surgical morbidity. PMID: 31753322 [PubMed - as supplied by publisher]
Conditions: Pain, Chronic; Sympathetic Disorder; Ultrasound Therapy Intervention: Device: ultrasound and CT Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting