Changes in total body surface area and the distribution of skin surfaces in relation to body mass index

ConclusionThe Wallace rule of nines is a quick and acceptable method for estimating the total burn surface area percentage in men of all BMI ranges. However, for women, a more accurate method of burn area estimation is required as proposed by our BMI adjusted charts.
Source: Burns - Category: Dermatology Source Type: research

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CONCLUSIONS: The evidence included in this review indicates that effective, scalable interventions addressing SSB consumption at a population level exist. Implementation should be accompanied by high-quality evaluations using appropriate study designs, with a particular focus on the long-term effects of approaches suitable for large-scale implementation. PMID: 31194900 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with FMT,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Cheng Luo1†, Xiqing Bian1†, Qian Zhang2, Zhenyan Xia1, Bowen Liu1, Qi Chen1, Chienchih Ke3,4, Jian-Lin Wu1* and Yonghua Zhao5* 1State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China 2Department of Biotherapy, Shenzhen Luohu People’s Hospital, Shenzhen, China 3Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 4Biomedical Imaging Research Center, National Yang-Ming University, Taipei, Taiwan 5State Key Laboratory of Quality Research in Chinese Medi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion Preclinical and clinical studies have demonstrated that treatment with antipsychotics and metformin had effects on the gut microbiota and the brain. Although the mechanism of the effects of metformin on AIMD remains unclear, there are some clues in the regulation of the gut-brain axis (Figure 1). The most important connections between metformin and AIMD in the gut microbiota were the mucin-degrading bacteria A. muciniphila and several SCFA-producing bacteria, such as the phyla Firmicutes and Bacteroidetes. The gut microbiota were was influenced during AIMD, and these changes included a decrease in A. muciniphil...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Treating burns effectively requires accurately assessing the percentage of the total body surface area (%TBSA) affected by burns. Current methods for estimating %TBSA, such as Lund and Browder (L&B) tables, rely on historic body statistics. An increasingly obese population has been blamed for increasing errors in %TBSA estimates. However, this assumption has not been experimentally validated. We hypothesized that errors in %TBSA estimates using L&B were due to differences in the physical proportions of today's children compared with children in the early 1940s when the chart was developed and that these differences would a...
Source: Journal of Surgical Research - Category: Surgery Authors: Tags: Burns Source Type: research
Conclusion This early-stage research suggests there is potentially a mechanism by which energy expenditure and storage is controlled in normal-weight mice versus obese mice. Removing a protein called hypothalamic TCPTP, which acts as the "switch" for fat storage, promoted weight loss in obese mice. This might give us some insight into how weight loss could be promoted in obese humans by turning this switch off. But at this stage, this is just a hypothesis – we can't assume the same is true for humans. Many therapies and procedures that appear promising at the outset aren't always successful in humans. Giv...
Source: NHS News Feed - Category: Consumer Health News Tags: Obesity Source Type: news
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span. Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This report captures the state of the research community in a nutshell: progress in the sense that ever more scientists are willing to make the treatment of aging the explicit goal of their research, but, unfortunately, there is still a long way to go in improving the nature of that research. It is still near entirely made up of projects that cannot possibly produce a robust and large impact on human life span. The only course of action likely to extend life by decades in the near future is implementation of the SENS vision for rejuvenation therapies - to repair the molecular damage that causes aging. Everything else on th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
By Dr. Sudip Bose, MD Dec. 31, 2016 -- As the 2016 presidential campaign came to a close and we elected a new president, polls showed that of the half-dozen things that most concerned Americans, health care was one of the major topics. No real surprise there. There are advocates for the Affordable Care Act, also known as Obamacare, who say that statistics show that 21 million more Americans got health care who didn't have it before, and that those least able to afford it were the ones who benefitted from the ACA. There are advocates against the Affordable Care Act who point to what they say is a broken system, with ins...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Conclusions This small trial aimed to see whether there is a difference between strictly controlled low-GI diets that contain the same amount of energy, but are either predominantly fat or carbohydrate based. Overall, researchers found the diets caused both weight and fat reduction, with little difference between the two – with the exception of minor differences in certain blood sugar and cholesterol markers, the significance of which is difficult to interpret. These could just be down to chance. The researchers were careful to control the diets and other lifestyle aspects to try to ensure any observed effects ...
Source: NHS News Feed - Category: Consumer Health News Tags: Diabetes Food/diet Source Type: news
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