Indication for and Effect of Adjuvant Chemotherapy for Stage IIa (T3N0M0) Colon Cancer.

CONCLUSION: Surgical oncologists consider the patient's condition and postoperative course rather than high-risk factors to determine use of AC. Regardless of AC use, both the extent of surgery and the patient's subsequent status affected the survival rate in the high-risk group. None of the factors identified influenced survival rate in the low-risk group. PMID: 31726001 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research

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This study was designed to compare the survival and surgical outcomes of laparoscopic colectomy (LC) in elderly and non-elderly patients with transverse colon cancer (TCC). METHODS: From January 2011 to January 2018, 44 elderly (aged ≥70 years) and 72 non-elderly (aged
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Rinat Bar-Shalom1, Margalit Bergman2, Shlomo Grossman2, Naiel Azzam1, Lital Sharvit1 and Fuad Fares1* 1Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel 2Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel Colorectal cancer (CRC) is the second most common cancer in females and the third in males worldwide. Conventional therapy of CRC is limited by severe side effects and by the development of resistance. Therefore, additional therapies are needed in order to combat the problem of selectivity and drug resistance in CRC patients. Inula viscosa (IV) is a well-...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study not only provides biological evidence to support the use of duloxetine as the first standard CIPN drug but will also lead to potential new targets for CIPN drug development. Introduction A major dose-limiting complication of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The greatest contributors to CIPN are taxanes (e.g., paclitaxel) and platinum-based (e.g., oxaliplatin) treatments (Krukowski et al., 2015). Paclitaxel (PTX) can effectively treat several of the most common cancers including breast cancer, lung cancer, and ovarian cancer (Ewertz et al., 2015; Cetinkaya-Fisgin et al., ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Similar short- and long-term outcomes can be achieved among elderly and middle-aged patients with right colon cancer who underwent laparoscopic complete mesocolic excision. Age is not a limiting factor in the application of laparoscopic complete mesocolic excision. PMID: 30610786 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Dr. Vincent Ng is an orthopaedic oncologist with the University of Maryland Greenebaum Comprehensive Cancer Center and an Assistant Professor or Orthopaedics with the University of Maryland School of Medicine.  Dr. Ng specializes in treating bone cancer and soft tissue sarcoma.  Below he answers common questions about orthopaedic oncology. What is an orthopaedic oncologist? How do they differ from surgical oncologists? “An orthopaedic oncologist specializes in bone and soft tissue tumors.  I treat any adult or pediatric patient with any bone or soft tissue tumor/lesion/mass, whether benign or malignan...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Cancer Doctors bone cancer oncology orthopedics Source Type: blogs
Authors: Kim YW, Choi EH, Kim BR, Ko WA, Do YM, Kim IY Abstract BACKGROUND: To examine the impact of chemotherapy delay on survival in patients with stage II or III colon cancer and the factors associated with the delay (≥8 weeks) of adjuvant chemotherapy. METHODS: Patients undergoing curative resection and adjuvant chemotherapy in a national population-based cohort were included. RESULTS: Among 5355 patients, 154 (2.9%) received chemotherapy more than 8 weeks after surgery. Based on a multivariate analysis, the risk factors associated with chemotherapy delay ≥8 weeks were older age [65 to 74 years (h...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Li C, Gao S, Li X, Li C, Ma L Abstract Colon cancer is one of the lethal varieties of cancer. Chemotherapy remains to be one of the principal treatment approaches for colon cancer. Anticancer activity of procaine (PCA), which is a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore the anticancer effect of PCA on colon cancer and its underlying mechanism. The results showed that PCA significantly inhibited cell viability, increased the percentage of apoptotic cells and decreased the expression level of RhoA in HCT116 cells in a dose dependent manner (P
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
CONCLUSION: The results demonstrate that the HAL-CME procedure is a safe, valid, and feasible surgical method for right hemicolon cancers. PMID: 28203556 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
How do we measure a doctor? Hospital length of stay? Infection rate? Flu shot compliance? Waiting time? These reality surrogates do not tell us how a patient feels or the quality of life. They are complex to measure, require major data crunching and may not focus on an individual physician. This week, two patients reminded me of a basic screening tool for good care: How much is the bill? 15 years ago, I took care of Melissa for gallbladder cancer. She received surgery, radiation and has been in remission ever since. In fact, because she has no need of a grouchy oncologist, I have not seen her in years. Melissa works f...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Conditions Cancer Source Type: blogs
Conclusion Epidural analgesia during colon cancer surgery was associated with a better overall survival. Prospective trials evaluating the effects of locoregional analgesia on colon cancer recurrence are warranted.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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