Genetic Analysis Can Surrogate the Treatment Strategies in Patients with Pancreatic Cancer.
Genetic Analysis Can Surrogate the Treatment Strategies in Patients with Pancreatic Cancer. Gut Liver. 2019 Nov 15;13(6):587-588 Authors: Kim DU PMID: 31724388 [PubMed - in process]
CONCLUSIONS: These data suggest that PIP5K1A and PIP5K1C could be target proteins for modulating MRP2 function, partly because of the resulting changes of the linker function of radixin. PMID: 31804920 [PubMed - in process]
The objective response rate (ORR) was 30% (10/33), including three complete responses (CR) (9.1%) and seven partial responses (PR) (21.2%) and a disease control rate (DCR = CR + PR + SD) of 66.7% (22 of 33). The most common adverse reactions, blistering, subcutaneous fat induration, local heat-related pain, vomiting and sinus tachycardia, were observed in association with HT. IL-2, IL-4, TNF-α, and IFN-γ levels in peripheral blood were significantly increased among the clinical responders (p
Conditions: Gastrointestinal Cancer; Colorectal Cancer; Pancreatic Cancer; Esophageal Cancer; Rectum Neoplasm; Esophageal Neoplasms; Pancreatic Ductal Adenocarcinoma; Colonic Neoplasms; Gastrointestinal Microbiome; Microbiota; Anastomotic Leak Intervention: Sponsor: Radboud University Not yet recruiting
Authors: Carmona S, Brunel JM, Bonier R, Sbarra V, Robert S, Borentain P, Lombardo D, Mas E, Gerolami R Abstract NV669 is an aminosterol derived from squalamine found to possess strong anticancer effects. The aim of this study was to investigate NV669's beneficial effects on human pancreatic and hepatic cancer models and to decipher the cellular and molecular mechanisms involved in tumor growth decrease upon treatment with NV669. Pancreatic (BxPC3, MiaPaCa-2) and hepatic (HepG2, Huh7) cancer cells were treated with NV669, and the effects recorded on proliferation, cell cycle and death. Results showed that NV669 inh...
A new "virtual biopsy" using ultrasound guidance allows doctors to definitively...Read more on AuntMinnie.comRelated Reading: USPSTF again dismisses pancreatic cancer screening New class of radiotracers targets many cancer types Can radiomics detect pancreatic ductal adenocarcinoma? Optical imaging finds small tumors
(Natural News) Pancreatic cancer is one of the most daunting varieties of the disease, with very few people surviving beyond five years after their diagnosis. With few symptoms, most patients aren’t diagnosed until they’ve already reached the metastatic stage. It’s the fourth leading cause of cancer deaths and the 12th most common type of cancer...
roren Expression of the small GTPase, Ras-related C3 botulinum toxin substrate 1B (RAC1B), a RAC1-related member of the Rho GTPase family, in tumor tissues of pancreatic ductal adenocarcinoma (PDAC) has been shown previously to correlate positively with patient survival, but the underlying mechanism(s) and the target genes involved have remained elusive. Screening of a panel of established PDAC-derived cell lines by immunoblotting indicated that both RAC1B and Mothers against decapentaplegic homolog 3 (SMAD3) were more abundantly expressed in poorly metastatic and well-differentiated lines as opposed to highly metastat...
Nature Reviews Gastroenterology &Hepatology, Published online: 06 December 2019; doi:10.1038/s41575-019-0242-7An area of research suggests a role for microbiota in the pathogenesis of pancreatic diseases, such as pancreatitis, pancreatic cancer and type 1 diabetes mellitus. In this Perspectives, the authors examine the literature implicating microorganisms in diseases of the pancreas as well as the evidence of an inherent pancreatic microbiota.