Determining the Polymorphism Information Content of a Molecular Marker.

Determining the Polymorphism Information Content of a Molecular Marker.
Gene. 2019 Nov 11;:144175
Authors: Lemos SCM, Lia Rejane Silveira R, Karol Buuron S, Silvia Machado Dos Santos R, Charlene Moro S
Abstract
This review was carried out with the purpose of contributing to the discussion on the equations used in calculating the Polymorphism Information Content (PIC) of molecular markers. PIC measures the ability of a marker to detect polymorphisms, and therefore has enormous importance in selecting markers for genetic studies. We perform a summary analysis of PIC and its difference in relation to heterozygosity, another parameter used to evaluate the quality of a marker, presenting and discussing the several equations registered in the literature for both dominant and codominant markers. Finally, we present a brief direction on estimating PIC for dominant markers.
PMID: 31726084 [PubMed - as supplied by publisher]

Source: Gene - November 10, 2019 Category: Genetics & Stem Cells Authors: Lemos SCM, Lia Rejane Silveira R, Karol Buuron S, Silvia Machado Dos Santos R, Charlene Moro S Tags: Gene Source Type: research