Inflammatory Breast Cancer: Diagnostic, Molecular and Therapeutic Considerations

AbstractPurpose of ReviewInflammatory breast cancer (IBC) is an aggressive type of breast cancer with poor prognosis. Treatment for non-metastatic disease is neoadjuvant chemotherapy followed by mastectomy and radiation. IBC diagnosis is primarily a clinical diagnosis, which can lead to misdiagnosis and delayed management. In addition, there are no molecular criteria for diagnosis or therapeutic regimens developed specifically for IBC. We aimed to discuss recent developments in IBC, including diagnosis, molecular mechanisms, and treatment.Recent FindingsRecently, the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC) breast cancer staging system has defined the diagnostic features of IBC. Current molecular characterization of IBC has not revealed a unique signature or marker for diagnosis; however, this work sheds light on the pathophysiology of IBC and provides potential therapeutic targets.SummaryThe prognosis of IBC remains poor, although the survival is improved significantly with trimodal management. To date, a consensus on diagnosis and prospective trials specifically designed for IBC therapy are lacking. Standardized criteria incorporating clinical, pathologic, and molecular criteria remains an unmet need. Recent consensus recommendations regarding diagnosis and management are reviewed with a view towards evolving molecular characterization, potential targets, and current clinical trials.
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research

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Authors: Huang Q, Xu TY, Wu ZY Abstract BACKGROUND As the most aggressive breast cancer, inflammatory breast cancer (IBC) has a poor prognosis. However, analyzing the prognostic factors of IBC is challenging due to its rarity. We identified the prognostic factors to establish predictive tools for survival in nonmetastatic IBC patients who received tri-modality therapy. MATERIAL AND METHODS The data of 893 nonmetastatic IBC patients were acquired from the Surveillance, Epidemiology, and End Results (SEER) database. IBC was identified by "ICD-O-3=8530" or "AJCC T, 7th=T4d"). Patients were randomiz...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
AbstractIn recent years, there has been a wider use of chemotherapy in the pre-operative setting for breast cancer (i.e., as neo-adjuvant chemotherapy). Most clinicians would agree that neo-adjuvant chemotherapy is justified for patients with inflammatory breast cancer, locally advanced breast cancer, or patients with large tumors and small breasts who are keen to undergo breast-conserving surgery. However, in the USA and many other western countries, neo-adjuvant chemotherapy is now used for greater numbers of breast cancer patients who do not fall within these categories. Yet, randomized trials have consistently shown th...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
This article explains the symptoms, treatment, and prognosis of the disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Breast Cancer Source Type: news
AbstractObjectivesThe aim of this analysis was to study the impact of marital status on inflammatory breast cancer (IBC) patients, as the prognostic impact is yet to be studied in detail.MethodsData of IBC patients from 2004 to 2010 were sorted out from the database of surveillance, epidemiology, and end results (SEER), and overall survival (OS) rates and breast cancer-specific survival (CSS) rates were compared between a group of married and unmarried patients. The comparison was performed by Kaplan –Meier method with log-rank test, and multivariate survival analysis of CSS and OS was performed using the Cox proport...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusion.Metastatic patterns of spread differ between patients with IBC and non‐IBC. Selection of patients with IBC with known liver, chest wall, and/or lung metastasis would create a population in whom to investigate effective methods for preventing future bone metastasis.Implications for Practice.This study demonstrated that the patterns of metastasis leading to and following bone metastasis differ significantly between patients with inflammatory breast cancer (IBC) and those with non‐IBC. Patients with IBC had a progression pattern that tended toward the development of bone metastasis if they had previously develo...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
ConclusionsWe identified an accurate predictor of response based on transcriptomic profiling by RNAseq, following a single dose of neoadjuvant dual-HER2 blockade in HER2-positive IBC. It outperforms a similar predictor constructed on a pretreatment profile in the same cohort. Assessing early-changes in gene expression level by RNA-seq following one dose of treatment may provide insights for the molecular mechanisms underlying response or resistance to anti-HER2 therapy.Clinical trial identificationNCT01796197.Legal entity responsible for the studyDana-Farber Cancer Institute.FundingGenentech, Inc and the Inflammatory Breas...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsPercutaneous endoscopy allowed us to approach the psoas and epidural abscesses directly, enabling the immediate drainage of the abscesses with less burden on the patient.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractPurpose of ReviewInflammatory breast cancer (IBC) is an uncommon but highly aggressive subtype of breast cancer that contributes significantly to breast cancer –related mortality. In this review, we provide an overview of the clinical and molecular characteristics of IBC, and highlight some areas of need for ongoing research.Recent FindingsThe disease is characterized by florid tumor emboli that obstruct dermal lymphatics, leading to swelling and inflammation of the affected breast. Recent studies have focused on tumor cell intrinsic features, such as signaling through pathways involved in growth and stem-lik...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
The present study aimed to examine the factors affecting survival of female patients with inflammatory breast cancer (IBC), as well as to construct and validate a nomogram to predict overall survival in IBC. AbstractIn the present study, we examined the factors affecting survival of women with inflammatory breast cancer (IBC) and constructed and validated a nomogram to predict overall survival (OS) in these patients. The cohort was selected from the Surveillance, Epidemiology, and End Results (SEER) program between 1 January 2004 and 31 December 2013. Univariate and multivariate Cox proportional hazards regression models w...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most lethal mammary cancers. An exacerbated angiogenesis and the existence of vasculogenic mimicry (VM) are hallmarks...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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