Local Failure After Accelerated Partial Breast Irradiation with Intraoperative Radiotherapy with Electrons: An Insight into Management and Outcome from an Italian Multicentric Study

ConclusionsRepeat quadrantectomy  + RT represents an effective salvage approach and achieved local control comparable to that of salvage mastectomy.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 5 December 2019Source: The LancetAuthor(s): Frank A Vicini, Reena S Cecchini, Julia R White, Douglas W Arthur, Thomas B Julian, Rachel A Rabinovitch, Robert R Kuske, Patricia A Ganz, David S Parda, Michael F Scheier, Kathryn A Winter, Soonmyung Paik, Henry M Kuerer, Laura A Vallow, Lori J Pierce, Eleftherios P Mamounas, Beryl McCormick, Joseph P Costantino, Harry D Bear, Isabelle GermainSummaryBackgroundWhole-breast irradiation after breast-conserving surgery for patients with early-stage breast cancer decreases ipsilateral breast-tumour recurrence (IBTR), yielding comparable results to m...
Source: The Lancet - Category: General Medicine Source Type: research
Conclusions and Relevance: For patients experiencing recurrence of breast cancer in the ipsilateral breast after lumpectomy and whole breast irradiation, a second breast conservation was achievable in 90%, with a low risk of re-recurrence of cancer in the ipsilateral breast using adjuvant partial breast reirradiation. This finding suggests that this treatment approach is an effective alternative to mastectomy. PMID: 31750868 [PubMed - as supplied by publisher]
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: JAMA Oncol Source Type: research
A 70-year-old female patient with a history of locally advanced breast cancer presented with a 2-month duration of persistent gait imbalance. Ten years earlier, she initially received a diagnosis of an invasive ductal carcinoma of the right breast, triple negative, treated with mastectomy and axillary lymph node dissection, followed by adjuvant chemotherapy and postmastectomy radiation therapy. She had been followed up without evidence of disease until the present time. Magnetic resonance imaging of the brain demonstrated a lobulated enhancing mass measuring 3.6  × 2.4 × 3.6 cm involvin...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
This study assesses the association between the choice of an HF versus conventionally fractionated (CF) regimen and completion.MethodsRT orders placed in 2016 and 2017 for patients with a national health plan, along with the associated claims, were extracted. Each order was assigned a target date for timely completion, as well as a date 30 days after the target, which was used to assess delayed completion. Univariate analyses and logistic regressions were conducted to test for an association between regimen and completion. A Poisson regression was used to examine the association between regimen and length of treatment dela...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The evidence map provides an overview of DCIS research showing the range of management options and remaining decisional dilemmas that follow a diagnosis of DCIS. It maps the evidence in accessible tools to guide practice and future research. Video Summary:http://links.lww.com/MENO/A448.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Abstract Immediate reconstruction after mastectomy helps women manage the psychological impact of deforming surgery. Postmastectomy radiation therapy (PMRT) can negatively impact the aesthetic result after breast reconstruction. We performed this study to achieve a better understanding of how PMRT is used after reconstruction in our institution. We conducted a retrospective review of a prospectively maintained database of all women who underwent mastectomy for invasive breast cancer followed by immediate reconstruction from 2006 to 2017. Patients were divided into two groups depending on whether PMRT was included ...
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
Among breast-cancer patients presenting with cN1 disease, nodal pathologic complete response (ypN0) after neoadjuvant chemotherapy (NACT) was associated with decreased likelihood of post-mastectomy and post-lumpectomy nodal radiation (NRT). There was no survival benefit associated with nodal (vs no) radiation in ypN0 patients post-mastectomy, but benefit approached significance among ypN1 patients. NRT was associated with improved survival for ypN0 and ypN1 patients post-lumpectomy but this benefit was not significantly greater than that conferred by breast-only radiation.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Authors: Josephine DSP Abstract OBJECTIVE: Lymphedema is a widespread complication after surgery or radiation therapy due to the damage and obstruction of the lymphatic vessels. A study was conducted to assess the effectiveness of lymphedema prevention protocol on quality of life among breast cancer patients with mastectomy at a selected hospital in Tamil Nadu. Objectives of the study were to identify the effect of lymphedema prevention protocol on lymphedema occurrence and quality of life. METHODS: A quantitative research approach of quasi experimental non-equivalent with control group before -after design (No...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions: Postoperative complications delay the commencement of radiation therapy in patients who received neoadjuvant chemotherapy and undergo mastectomy with immediate breast reconstruction. The period from the last dose of neoadjuvant chemotherapy was equivalent between those that experienced postoperative complications and those that did not. Patients with a higher body mass index are more likely to experience postoperative complications, and this should be considered when offering tissue expanders to obese patients who have received neoadjuvant chemotherapy and require adjuvant radiation treatment. CLINICAL QUES...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Breast: Original Articles Source Type: research
ConclusionTumor size and grade seem to be reliable predictors of survival in both PAS and SAS. Mastectomy does not seem to be adding any additional benefit to BCS. Adjuvant radiation therapy showed statistically significant RFS benefit, while adjuvant chemotherapy can be beneficial in high grade tumors.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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