Systemic sclerosis induced by CNS stimulants for ADHD: A case series and review of the literature

ConclusionThis is the first report in the literature of a causative relation between methylphenidate and the development of SSc, a serious, life-threatening condition. Patients treated with CNS stimulants should be followed closely for side-effects such as RP and skin changes.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research

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Conclusion: Our results may demonstrate that while externalization symptoms were associated with hyperactivity/impulsivity symptoms of ADHD, the internalization symptoms were significantly related to SCT in youngs with ADHD. Specifically, although social withdrawal was significantly related to ADHD-inattention, this relationship was mediated by the severity of SCT. PMID: 31809238 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Authors: Smith RE, Hunt RR Abstract An important discovery in false-memory research is Israel and Schacter's (Psychonomic Bulletin &Review, 4, 577-581, 1997) finding that presenting pictures at study relative to words alone reduces false memory in the DRM paradigm, a result that has been replicated many times. The standard interpretation is that memory for visual processing of the pictures can be used to reject the critical distractors, which were not explicitly present at study. Beginning from the empirical observation that the pictures used by Israel and Schacter are not consistently labelled with the DRM wor...
Source: Memory and Cognition - Category: Neuroscience Tags: Mem Cognit Source Type: research
The objective of the present study was to assess serum trace element and mineral levels in children with ADHD.MethodsSerum trace element and mineral levels in 68 children with ADHD and 68 neurotypical controls were assessed using ICP-MS at NexION 300D (PerkinElmer Inc., USA) equipped with ESI SC-2 DX4 autosampler (Elemental Scientific Inc., USA).ResultsSerum Cr, Mg, and Zn levels in children with ADHD were 21% (p = 0.010), 4% (p = 0.005), and 7% (p = 0. 001) lower as compared to the healthy controls, respectively. In turn, serum Cu/Zn values were 11% higher than those in the contro...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
This week’s Psychology Around the Net takes a look at what to do if you think your child is at risk for mental illness, why self-regulation is so important for people with ADHD, the symptoms of problematic smartphone use, and the mental and physical fatigue that often accompanies chronic illness, and more.     Does Mental Illness Run in Families?: What should you do if you suspect your child is at risk of developing a mental disorder — especially when mental illness runs in your family? According to psychologist Scott Bea PsyD, an important first step is helping your child build resilience, a persona...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: ADHD and ADD Anxiety and Panic Autism Children and Teens Depression Disorders Family General Health-related Mental Health and Wellness Parenting Psychiatry Psychology Psychology Around the Net Research Asd Bipolar Disorder Source Type: blogs
Authors: Stavorn T, Chanprapaph K Abstract Degos disease is characterized by atrophic porcelain-white papules with peripheral erythema. Degos-like lesions have been reported in association with several connective tissue diseases (CTDs), mostly systemic lupus erythematosus (SLE), and rarely in dermatomyositis and systemic sclerosis. Herein, we report three cases of Degos-like lesions in CTDs. Two cases had Degos-like lesions linked to dermatomyositis. Both cases presented with severe inflammatory myopathy without pathognomonic cutaneous signs for dermatomyositis and lacked myositis-specific autoantibodies. Our third...
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Petcu A, Ghib LJ, Grad SM, Popovici C, Rogojan L, Rednic NV, Rednic S Abstract Gastrointestinal tract involvement is the most common visceral affectation in systemic sclerosis (SSc), but the manifestations may vary in extension and severity. Endoscopic and histopathological gastroesophageal findings were investigated in patients with SSc. A total of 79 consecutive patients with definite SSc were enrolled in a cross sectional study. Clinical data were collected, upper gastrointestinal endoscopy and biopsies from gastric mucosa were performed in all cases. Fifty-seven (72.1%) out of 79 SSc patients had gastr...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
This study was registered at ClinicalTrials.gov (NCT02896205).
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractPurpose of ReviewArthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM.Recent FindingsArthritis is reported in 18 –55% of patients with IIM. It is particularly frequent (20–70%) in those with antisynthetase syndrome (ASS); highest prevalence is associated with anti-Jo-1 positivity. Most common manifestation is non-erosive polyarthritis. X-ray erosions may be found occasionally in ASS, particularly in patien t...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
AbstractPurpose of the ReviewSystemic sclerosis (scleroderma) is a complex autoimmune disease that commonly involves the cardiovascular system. Even if often subclinical, cardiac involvement is considered a poor prognostic factor as it is a leading cause of death in scleroderma patients. We review the cardiac manifestations of scleroderma, the diagnostic methods useful in detection, and current advances in therapeutic management.Recent FindingsBeside the routine exams for the assessment of cardiac status (including EKG, standard echocardiography, provocative tests) novel techniques such as myocardial strain imaging on echo...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
AbstractPurpose of ReviewEpigenetics has been implicated in the pathogenesis of systemic sclerosis (SSc). In this review, the involvement of the three epigenetic mechanisms in SSc development and progression —DNA methylation, histone modifications, and non-coding RNAs—will be discussed.Recent FindingsAlteration in epigenetics was observed in immune cells, dermal fibroblasts, and endothelial cells derived from SSc patients. Genes that are affected include those involved in immune cell function and differentiation, TGF β and Wnt pathways, extracellular matrix accumulation, transcription factors, and angiogen...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
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