Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

Publication date: Available online 15 November 2019Source: Autoimmunity ReviewsAuthor(s): José María G. Ruiz de Morales, Lluís Puig, Esteban Daudén, Juan D. Cañete, José Luis Pablos, Antonio Olveira Martín, Carlos González Juanatey, Alfredo Adán, Xavier Montalbán, Natalia Borruel, Guillermo Ortí, Esther Holgado Martín, Carolina García-Vidal, Cynthia Vizcaya Morales, Víctor Martín Vázquez, Miguel Ángel González-GayAbstractInterleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. In this context, the present review in which a panel of 13 experts in immunology, dermatology, rheumatology, neurology, hematology, infectious diseases, hepatology, cardiology, ophthalmology and oncology have been involved, puts in common the mechanisms through which IL-17 is considered a molecular target for the development of novel biological therapies in these different fields. A comprehensive review of the literature and analysis of the most outstanding evidence have provided the basis for discussing the most relevant data related to IL-17A blocking agents for the treatment of different disorders, such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, cardiovascular disorders, non alcoholic fatty liver ...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 24 October 2019Source: Practical Radiation OncologyAuthor(s): Bram D. Vermeulen, Paul M. Jeene, Jasmijn Sijben, Robin Krol, Heidi Rütten, Johannes A. Bogers, Pètra M. Braam, Peter D. SiersemaAbstractPurposeClinical evidence regarding optimal radiation dose for palliation of dysphagia from esophageal cancer is generally lacking. In an effort to investigate optimal radiation dose, we assessed 2 different radiation schedules for palliation of dysphagia.Methods and MaterialsWe performed a multicenter, retrospective study comparing low-dose radiation therapy (LR: 5 x 4 Gy external ...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 December 2019Source: Journal of Geriatric OncologyAuthor(s): Birgit van Ee, Joris Slaets, Carolien Smits, Aafke Honkoop, Ad Kamper, Mariët Hagedoorn
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 December 2019Source: Cancer EpidemiologyAuthor(s): Ashley E. Stenzel, Kirsten B. Moysich
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionWe have shown that GP-identified instances of avoidable delay have construct validity. Whilst the causes of avoidable diagnostic delays are multi-factorial and occur in different settings and phases of the diagnostic process, their analysis can guide improvement initiatives and enable the examination of any prognostic implications.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Hyperthermic Mitomycin using the HIVEC® device is a rather safe and well tolerated treatment. Efficiency remains partial as 27.3% of patients experienced recurrence during the first year. These data should be confirmed by prospective multicentric studies. PMID: 31787540 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
The US Food and Drug Administration approved the immunotherapy as initial treatment of metastatic nonsquamous non-small cell lung cancer (mNSCLC).Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Publication date: 15 February 2020Source: Materials Chemistry and Physics, Volume 242Author(s): A.S. Rajashekharaiah, G.P. Darshan, H.B. Premkumar, P. Lalitha, S.C. Sharma, H. NagabhushanaAbstractNano biotechnology is rapidly growing eco-friendly research area and used in various broad sections, such as biology, chemistry, physics, biomedicine and material engineering. The synthesis of highly efficient, non-toxic, inexpensive and environmental friendly nanomaterial is an urgent need. The aim of the present work was assessment of anti-oxidant, anti-bacterial and cytotoxicity potentials of Bi2Zr2O7:Dy3+ (1–11 mol ...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: Available online 3 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Manon Meyrel, Benjamin Rolland, Pierre A. GeoffroyAbstractIncreasing evidence suggest a bidirectional link between disrupted circadian rhythms and alcohol use disorders (AUD). A better understanding of these alcohol-induced changes in circadian rhythms will likely provide important therapeutic solutions. We conducted a systematic review based on the PubMed database examining biological rhythms in all stages of alcohol use: acute alcohol consumption, AUD, alcohol withdrawal, and abstinence. Diff...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Publication date: 3 December 2019Source: Cell Reports, Volume 29, Issue 10Author(s): Brett S. Marro, Jaroslav Zak, Reza Beheshti Zavareh, John R. Teijaro, Luke L. Lairson, Michael B.A. OldstoneSummaryInhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape from immune surveillance and continuation of disease. Here, we report the design, implementation, and results of a phenoty...
Source: Cell Reports - Category: Cytology Source Type: research
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