Modelo predictivo de la funcionalidad en la esquizofrenia: una aproximación desde el modelado de ecuaciones estructurales

ConclusionesLos resultados indican que los síntomas negativos y el funcionamiento premórbido predicen directamente la funcionalidad, mientras que los factores cognitivos muestran interacciones más complejas con los síntomas negativos y la funcionalidad. Estos resultados deberían ser considerados para nuevas estrategias de intervención.AbstractIntroductionAlthough it is well-known that several factors such as symptoms and cognition are related with functional outcome in schizophrenia, the complex nature of the disorder makes necessary to study their interaction by means of a more analytic method than simple linkages approaches.Material and methodsOne hundred and sixty-five patients with schizophrenia underwent a clinical evaluation (including clinical symptoms, insight, affective symptoms and premorbid adjustment). Neurocognition was represented by a 5-factor structure obtained by confirmatory factor analysis from a neurocognitive battery. The estimation for outcome was obtained throughout the DAS-WHO scale, and quality of life with the Quality of Life Scale.ResultsUsing structural equation modeling (SEM), specifically measured-variable path analysis, a mediational model consisting of neurocognitive capacity linked to clinical symptoms and premorbid functioning showed good fit to the observed data (Satorra-Bentler χ2 = 604.83; RMSEA = .08; SRMR = .11; NNFI = .96; CFI = .97). Processing speed, verbal memory and premorbid ...
Source: Revista de Psiquiatria y Salud Mental - Category: Psychiatry Source Type: research