A novel voxel-based method to estimate cortical sulci width and its application to compare patients with Alzheimer's disease to controls

Publication date: Available online 14 November 2019Source: NeuroImageAuthor(s): Maria Julieta Mateos, Alfonso Gastelum Strozzi, Fernando A. Barrios, Ernesto Bribiesca, Sarael Alcauter, Jorge Marquez FloresAbstractA voxel-based method for measuring sulcal width was developed, validated and applied to a database. This method (EDT-based LM) employs the 3D Euclidean Distance Transform (EDT) of the pial surface and a Local Maxima labeling algorithm. A computational phantom was designed to test method performance; results revealed the method's inaccuracy δ, to range between 0.1 and 0.5 voxels, for a width that varied between 1 and 7 voxels. Two morphological descriptors were computed to characterize each defined sulcus: mean sulcal width (MSW) and mean absolute deviation (MAD). The former is the average width for all available width measurements within the sulcus, and the latter is the deviation of these measurements. The EDT-based LM method was applied to the Minimal Interval Resonance Imaging in the Alzheimer's Disease (MIRIAD) database, for a set of high-resolution Magnetic Resonance (MR) images of 66 subjects: 43 patients with Alzheimer Disease (AD) and 23 control subjects. AD causes significant gray matter loss; hence, some sulci were expected to broaden. Methodological results concurred with this hypothesis. After a Wilcoxon test, MSW was grater in the case of all sulci pertaining to AD patients, (p 
Source: NeuroImage - Category: Neuroscience Source Type: research

Related Links:

This study aims to describe the gender and age differences in the incidence and prevalence of dementia and AD in Taiwan. Methods: The data on dementia and AD were acquired from the Taiwan National Health Insurance Research Database from 2004 to 2010. The sex and age-specific rates were standardized, and the differences of gender and age on dementia or AD were assessed using Poisson regression analysis. Results: Over seven years, the prevalence of dementia and AD significantly increased from 4.7 to 7.6 per hundred people (β = 0.0784, p
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour. Striatum, which is a component of the basal ganglia, is involved in facilitating voluntary movement while the cerebellum is involved in the maintenance of balance and coordination of voluntary movements. Dopamine, serotonin, gamma-aminobutyric acid (GABA), and glutamate, to name a few, interact in regulating the excitation and inhibition of motor neuro...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSIONS These data suggest that FXR regulates Aß-induced neuronal apoptosis, which may be dependent on the CREB/BDNF signaling pathway in vitro. PMID: 31812977 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsThis study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
In this study, we investigated the effect of long-term 30% CR compared with ad libitum (AL) feeding on the microbiome in aging. We studied the Tg2576 model, where a mutant variant of the human APP is expressed in transgenic mice. This transgene results in cerebral amyloid accumulation, synaptic loss, and cognitive impairment by 12 months of age. We found that female Tg2576 mice have more substantial age-related microbiome changes compared to wildtype (WT) mice, including an increase in Bacteroides, which were normalized by CR. Specific gut microbiota changes were linked to Aβ levels, with greater effects in females th...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conclusions: In conclusion, we identified the extensive landscape of altered genes and pathways in colorectal cancer liver metastasis, which will be useful to design clinical therapy for personalized medicine. PMID: 31814826 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
The proteins amyloid beta and tau work together and hamper brain messaging, researchers at the University of Edinburgh found after looking at brain tissue from mice and humans.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Shah Islam Hugh Harvey By HUGH HARVEY, MBBS and SHAH ISLAM, MBBS AI in medical imaging entered the consciousness of radiologists just a few years ago, notably peaking in 2016 when Geoffrey Hinton declared radiologists’ time was up, swiftly followed by the first AI startups booking exhibiting booths at RSNA. Three years on, the sheer number and scale of AI-focussed offerings has gathered significant pace, so much so that this year a decision was made by the RSNA organising committee to move the ever-growing AI showcase to a new space located in the lower level of the North Hall. In some ways it made sense to ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Start-Ups AI Hugh Harvey Radiology RSNA RSNA 2019 RSNA19 Shah Islam Source Type: blogs
Can you distinguish the taste of a red wine versus a rosé? How about the look of a 1960s muscle car versus a foreign import? Do you prefer to grow lilies or tulips? Would you rather listen to Dark Side of the Moon or “Fly Me to the Moon”? To answer any of these questions, you need to use your semantic memory. Your semantic memory is your store of factual knowledge of the world and the meaning of words. It’s how you know that a fork is for eating (not twirling your hair) and what color a lion is. It’s both the source of your vocabulary and how you know what something does even if you don&rsquo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Healthy Aging Memory Source Type: blogs
C2N Diagnostics’s detection test for Alzheimer’s disease is showing off some strong data coming out of the 12th Annual Clinical Trials in Alzheimer’s Disease conference. The St. Louis-based company said results from a study show the Aptus-Aβ test strongly predicts the presence of brain amyloidosis in a diverse population. C2N Diagnostics said its blood-based in vitro diagnostic is being developed to predict amyloid PET scan results. It combines into a ratio, the concentration of amyloid beta (Aβ) isoforms Aβ42 and Aβ40 in ...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
More News: Alzheimer's | Brain | Databases & Libraries | Neurology | Neuroscience