Glutamine Improves Oxidative Stress through the Wnt3a/ β-Catenin Signaling Pathway in Alzheimer's Disease In Vitro and In Vivo.

Conclusion: This study suggests that glutamine could protect against oxidative stress-induced injury in AD mice via the Wnt3a/β-catenin signaling pathway. PMID: 31119171 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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In this study, we comparatively evaluated total phenolic content, antioxidant capacity, and neuroprotective effects of the phlorotannin-rich extract from E. cava (PEEC). The total phenolic content of PEEC and dieckol was 810.8 mg gallic acid equivalents (GAE)/g and 996.6 mg GAE/g, respectively. Antioxidant capacity of PEEC was 1,233.8 mg vitamin C equivalents (VCE)/g and 392.1 mg VCE/g determined using ABTS and DPPH assays, respectively, while those of dieckol were 2,238.4 mg VCE/g and 817.7 mg VCE/g. High-performance liquid chromatography results revealed 48.08 ± 0.67 mg dieckol/g of PEEC. PEEC had neuroprotective ...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research
Nerve growth factor (NGF) is a promising neuroprotective drug for Alzheimer's disease, however, its delivery to the brain remains a challenge. NGF is incorporated in degradable porous silicon carriers, showing a continuous, sustained, and effective release for over a month. Toward clinical use, the administration of the carriers to murine brain by either direct implantation or biolistically is demonstrated. AbstractNerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
This study is focused on the Wnt/β-catenin pathway influence on Tau phosphorylation and the distribution of microtubules and neurofilaments in adrenal pheochromocytoma cells. It was found that neurofilament heavy polypeptide and microtubule-associated protein-2 aggregated after treatment with Aβ₁₋₄₂. Treatment with Wnt5a reduced this aggregation, while Dickkopf-1 treatment promoted microtubule and neurofilament aggregation. Furthermore, Tau phosphorylation at Ser396, Ser422, and Ser199 was significantly reduced after Wnt5a treatment, whereas Dickkopf-1 increased the level of phosphorylation. These results...
Source: Journal of Integrative Neuroscience - Category: Neuroscience Authors: Tags: J Integr Neurosci Source Type: research
Nerve growth factor (NGF) is a promising neuroprotective drug for Alzheimer's disease, however, its delivery to the brain remains a challenge. NGF is incorporated in degradable porous silicon carriers, showing a continuous, sustained, and effective release for over a month. Toward clinical use, the administration of the carriers to murine brain by either direct implantation or biolistically is demonstrated. AbstractNerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
In this study, the activities of N-acetyl chitooligosaccharides (NA-COS), the hydrolytic products of chitin, were evaluated using Aβ-induced damages in animal and cell models of AD. Our results demonstrated that NA-COS significantly improved both acquisition (learning) and retention (memory) of AD rats on water maze task. HE staining of brain tissue sections showed that NA-COS could ameliorate hippocampal neurodegeneration induced by Aβ25-35. Further biochemical analysis showed that NA-COS treatment of intrahippocampal Aβ-microinjected rats was able to elevate choline acetyltransferase activity and attenuate...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ1-42-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβ1-42 fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibri...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
In this study we investigated the role of ceramide and S1P on APP metabolism. Moreover, the effect of ceramide and SEW 2871 (agonist for S1P receptor-1) on Sirt1 (NAD+-dependent nuclear enzyme responsible for stress response) gene expression under A toxicity was analyzed. Experiments were carried out using pheochromocytoma cells (PC-12) transfected with: an empty vector (used as a control), human wild-type APP gene (APPwt) and Swedish mutated (K670M/N671L) APP gene (APPsw). Our results indicated that C2-ceramide significantly decreased the viability of the APPwt, APPsw as well as empty vector-transfected PC12 cells...
Source: Folia Neuropathologica - Category: Pathology Authors: Tags: Folia Neuropathol Source Type: research
CONCLUSION: These results together with previous findings strongly corroborated Tau's involvement in NAP/ADNP cellular activity. PMID: 30417779 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Publication date: Available online 13 October 2018Source: Life SciencesAuthor(s): Chunyan Zhang, Linsen Xie, Fangxia Guan, Yuanbo CuiAbstractAimsIncreasing evidence displays that deposition of aggregated β-amyloid (Aβ) leads to neuronal cell apoptosis, thus aggravates the pathological progression of Alzheimer's disease (AD). 3H-1,2-dithiole-3-thione (D3T) has been proved to exert neuroprotective effects. However, the effect of D3T on protecting against Aβ-induced apoptosis and the underlying mechanism are unknown.Main methodsMTT, DCFH-DA assay, LDH release assay, Fluo-3 AM assay, Flow cytometry and Western...
Source: Life Sciences - Category: Biology Source Type: research
AbstractSympathetic neuroimaging is based on the injection of compounds that either radiolabel sites of the cell membrane norepinephrine transporter (NET) or that are taken up into sympathetic nerves via the NET and radiolabel intra-neuronal catecholamine storage sites. Detection of the radioactivity is by planar or tomographic radionuclide imaging. The heart stands out among body organs in terms of the intensity of radiolabeling of sympathetic nerves, and virtually all of sympathetic neuroimaging focuses on the left ventricular myocardium. The most common cardiac sympathetic neuroimaging method worldwide is123I-metaiodobe...
Source: Clinical Autonomic Research - Category: Research Source Type: research
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