Post-transfusion platelet responses in critically ill cancer patients with hypoproliferative thrombocytopenia.

Post-transfusion platelet responses in critically ill cancer patients with hypoproliferative thrombocytopenia. Transfusion. 2019 Nov 14;: Authors: Baron E, Charpentier J, François A, Ben Hadj Amor H, Habr B, Cariou A, Chiche JD, Mira JP, Jamme M, Pène F Abstract BACKGROUND: Platelet transfusion is aimed at increasing platelet counts to prevent or treat bleeding. Critically ill cancer patients with hypoproliferative thrombocytopenia are high consumers of blood products. We herein described their post-transfusion platelet responses in the intensive care unit (ICU) and analyzed the determinants of poor post-transfusion increments. STUDY DESIGN AND METHODS: This was a single-center 9-year (2009-2017) retrospective observational study. Patients with malignancies and presumed or proven hypoproliferative thrombocytopenia who had received at least one platelet transfusion in the ICU were included. Poor post-transfusion platelet increments were defined as body surface-adjusted corrected count increment (CCI) 
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research

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CONCLUSION: patients with a history of exposure to heparin, patients with fresh thrombosis or spontaneous bleeding of unknown origin should pay attention to HIT screening. We should consider the possibility of HIT when patients have high fever and thrombocytopenia. PMID: 31818535 [PubMed - as supplied by publisher]
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