Michigan Boy, 17, Gets Double Lung Transplant After Damage From Vaping Michigan Boy, 17, Gets Double Lung Transplant After Damage From Vaping

A 17-year-old Michigan boy facing"imminent death" from vaping injuries has undergone a double lung transplant, the first in a patient suffering from the effects of e-cigarettes, a Detroit hospital said on Tuesday.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Pediatrics News Source Type: news

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Purpose of review This review provides a risk-stratified and evidence-based management for subsets of systemic sclerosis (SSc) patients in the first five years from disease onset. Recent findings Cardiopulmonary disease remains the primary cause of mortality in SSc patients. Morbidity and mortality in SSc-associated pulmonary arterial hypertension have improved with combination treatment, in either an upfront or sequential treatment pattern. Traditional therapies for interstitial lung disease (SSc-ILD) have targeted those with clinically significant and progressive ILD with immunosuppression. New data suggest a possib...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: CLINICAL THERAPEUTICS AND HEMATOLOGIC COMPLICATIONS: Edited by W. Joseph McCune Source Type: research
Purpose of review Summarize recent evidence on the identification and management of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Recent findings Clinical and subclinical interstitial lung disease (ILD) are frequent extra-articular manifestations of rheumatoid arthritis (RA). Better means of identifying and treating RA-ILD are needed to improve the prognosis, with a median survival of only 3–7 years after diagnosis. Several serum biomarkers are currently being evaluated for their ability to detect RA-ILD. Thorough evaluation and multidisciplinary discussion remains the gold standard for est...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: RHEUMATOID ARTHRITIS: Edited by Joshua F. Baker Source Type: research
Publication date: Available online 27 March 2020Source: The Annals of Thoracic SurgeryAuthor(s): Hiromichi Niikawa, Toshihiro Okamoto, Kamal S. Ayyat, Ichiro Sakanoue, James J. Yun, Kenneth R. McCurry
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractCleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed against the MUC1 alpha –beta junction comprising the SEA domain, a stable cell-surface moiety, were generated. Sequencing of all seven anti-SEA domain mAbs showed that they clustered into four groups and sequences of all groups are presented here. mAb DMB5F3 with picomolar affinity for the MUC1 SEA target was selected f or further evaluation. Immunohistochemical staining of a series of malignancies with DMB5F3 including lung, prostate, breas...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
AbstractThis review appraises the current literature on carcinogenic risks in anti-neutrophilic cytoplasmic autoantibody (ANCA) associated vasculitis (AAV). Patients with AAV are often at increased risk of developing non-melanoma skin carcinomas (NMSCs), haematological malignancies, bladder, breast, lung, prostate, and colorectal carcinomas. Reported cancer incidence in these patients ranged from 10 to 26%. Cancer risks at the time of diagnosis of AAV and disease outcomes along the trajectory of AAV that may lead to chronic kidney disease (CKD); dialysis and transplantation are summarized. Inherent carcinogenic risks as pa...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
In Reply We thank Tian et al for their letter and interest in our article. We agree with the authors that ex vivo lung perfusion (EVLP), regardless of platform, has consistently been shown to provide short-term outcomes similar to those of conventional lung transplantation. In our article, we focused on the longer-term outcomes, and these too were similar between EVLP-treated and non-EVLP donor lungs.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
To the Editor We read with great interest the article by Divithotawela et al, which demonstrated the posttransplant long-term outcomes were similar between ex vivo lung perfusion (EVLP) –treated lung transplant (LTx) and standard LTx, although the quality of donor lungs was worse with EVLP-treated LTx. To our knowledge, this study is the largest study of EVLP and includes 230 EVLP cases. We congratulate Divithotawela et al for this excellent study.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
PMID: 32209030 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
The epidemiological and clinical characteristics of heart transplant (HTx) recipients during the SARS-CoV-2 epidemic remains unclear. We studied the characteristics of HTx recipients during Dec 20, 2019 and Feb 25, 2020 in an effort to understand their risk and outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Condition:   Lung Transplant Failure and Rejection Intervention:   Diagnostic Test: Allosure Sponsors:   Pablo Sanchez;   CareDx Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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