Impact of baseline calibration on semiquantitative assessment of myocardial perfusion reserve by adenosine stress MRI

In this study, we sought  to investigate the impact of baseline calibration, which is used in quantitative cardiac MRI perfusion analysis to correct for surface coil inhomogeneity and noise, on myocardial perfusion reserve index (MPRI) and its contribution to previously reported paradoxical low MPRI 
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research

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ConclusionsBrain cytokine concentrations are unaffected by perfusing with saline prior to tissue collection; this holds true regardless of immune status (homeostatic or immune challenged), suggesting that this time-consuming step may be unnecessary.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: Available online 23 January 2020Source: MethodsAuthor(s): Jean de Montigny, Alexandros Iosif, Lukas Breitwieser, Marco Manca, Roman Bauer, Vasileios VavourakisAbstractThis paper develops a three-dimensional in silico hybrid model of cancer, which describes the multi-variate phenotypic behaviour of tumour and host cells. The model encompasses the role of cell migration and adhesion, the influence of the extracellular matrix, the effects of oxygen and nutrient availability, and the signalling triggered by chemical cues and growth factors. The proposed in silico hybrid modelling framework combines successful...
Source: Methods - Category: Molecular Biology Source Type: research
Conclusion: The BFACME appears to exert a hypoglycemic activity by potentiating the insulin action.Keywords: Artemisia campestris; hypoglycemic activity; isolated perfused rat liver; rats.
Source: African Health Sciences - Category: African Health Source Type: research
ConclusionThis study provides the branching characteristics and hemodynamic analysis of the left coronary arterial circulation of a human heart. The resulting model can be deployed for further hemodynamic studies at the whole organ and local level.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionEstrogen regulates duodenal calcium absorption through differential role of ER ɑ and ERβ on duodenal epithelial cellular TRPV6 and PMCA1b. The study further elucidates the mechanism of estrogen on the regulation of intestinal calcium absorption.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
ConclusionsDirect perfusion of a left carotid bypass proved to be cerebroprotective, resulting in a more physiological and stable anterior and posterior cerebral perfusion.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Multiple renal arteries are a common renal vascular variant. A study with 800 kidneys from cadaver donors demonstrated 1% prevalence of quadruple renal arteries.1 During thoracoabdominal aortic aneurysm (TAAA) repair, this anomaly implies longer time of renal ischemia and well-defined reperfusion strategy.2 Acute kidney injury during TAAA repair is a common complication with 6% to 7% incidence.3,4 It can be prevented by histidine-tryptophan-ketoglutarate solution (Custodiol; Dr Franz-K öhler Chemie GmbH, Bensheim, Germany) renal perfusion.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Vascular images Source Type: research
Suprarenal abdominal aortic coarctation (SAAC) is a congenital midaortic syndrome that develops owing to a developmental anomaly in the fusion of the embryonic dorsal aortae. This condition is associated with severe hypertension, which is usually the indication for intervention. Open surgery is the primary treatment and it typically involves thoracoaortic bypass (TAB), and less commonly patch aortoplasty (PA). Bypass to the visceral vessels has also been performed in conjunction with TAB or PA. The majority undergoing intervention for SAAC are children and adolescents; therefore, the benefits of surgical intervention must ...
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Invited commentary Source Type: research
We present the case of a 46-year-old woman with a presumed diagnosis of multiple unprovoked pulmonary emboli. Her cardiorespiratory function continued to deteriorate despite optimal medical therapy. At surgical thrombectomy she was identified to have an intimal soft tissue lesion arising from the right pulmonary artery. This lesion was subsequently diagnosed as a pulmonary artery sarcoma, a rare neoplasm that carries a poor prognosis. It typically presents at an advanced stage with pulmonary vascular obstruction. Surgical debulking is the mainstay of therapy to restore ventilation perfusion mismatching and relieve right-si...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: February 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 2Author(s): Elizabeth L. Norton, Xiaoting Wu, Linda Farhat, Karen M. Kim, Himanshu J. Patel, G. Michael Deeb, Bo YangBackgroundIt is controversial if extension of aortic dissection into arch branches should be an indication for replacement of the arch and its branches in acute type A aortic dissection.MethodsFrom 2008 to April 2018, 399 patients underwent open repair for an acute type A aortic dissection, and 190 patients had known innominate and/or left common carotid artery dissection without malperfusion syndrome, including no arch ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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