A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine.

A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine. J Pharm Pharm Sci. 2019;22(1):536-547 Authors: Uddin MN, Henry B, Carter KD, Roni MA, Kouzi SS Abstract Human papillomaviruses (HPV) are small, double-stranded DNA viruses that cause cervical cancer, the second most lethal cancer among women in the world. Currently, two vaccines are on the market for preventing HPV-caused cervical cancers and warts. Both are virus-like particle (VLP)-based vaccines. However, these vaccines have limitations; they are costly, have an invasive route of administration, require trained personnel to administer, need cold chain storage to preserve them, and most of all, they are preventive vaccines that do not have curative effects. Therefore, it is necessary to develop therapeutic HPV vaccines to facilitate the control of HPV-associated malignancies and to address all these issues. Recently there are DNA vaccines under investigation to prevent HPV. In general, DNA-based vaccines are better than or an excellent alternative to traditional vaccines since they can closely mimic live infections and can induce both antibody and cell-mediated immune responses. DNA vaccines involve the delivery of plasmid DNA (pDNA) which encodes the specific antigens. DNA vaccines have potential to be effective therapeutic tools against HPV infections. Combining the VLP-based and DNA-based vaccines can be highly effective as they can complement each other. VLP vaccines ar...
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research

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By Jacqueline Howard, CNN (CNN) — The US Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, known as ACIP, voted unanimously on Wednesday to recommend HPV vaccines for both boys and girls and men and women through age 26. Previously the CDC recommended that teen girls and young women who had not been adequately vaccinated receive the human papillomavirus vaccine through age 26, but the recommendation for teen boys and young men only went through age 21. The CDC’s recommendation that children start receiving two doses of the HPV vaccine around 11 or 12...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN HPV vaccine Source Type: news
In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 26 March 2019Source: Antiviral ResearchAuthor(s): Lukai Zhai, Rashi Yadav, Nitesh K. Kunda, Dana Anderson, Elizabeth Bruckner, Elliott K. Miller, Rupsa Basu, Pavan Muttil, Ebenezer TumbanAbstractHuman papillomaviruses (HPVs) are the most common sexually transmitted infections. HPVs are transmitted through anogenital sex or oral sex. Anogenital transmission/infection is associated with anogenital cancers and genital warts while oral transmission/infection is associated with head and neck cancers (HNCs) including recurrent respiratory papillomatosis. Current HPV vaccines protect against HPV...
Source: Antiviral Therapy - Category: Virology Source Type: research
CONCLUSION: The results underscored the necessity to develop health education and promotion aimed at improving the knowledge and vaccination practice in immigrants and refugees. PMID: 30420043 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Adults up to age 45 can now be vaccinated against human papillomavirus (HPV), reducing their chances of getting cervical, oral and other cancers. The Food and Drug Administration (FDA) announced Friday that Gardasil 9, a vaccine that works against nine different types of HPV, is now approved for both men and women between the ages of 27 and 45. Previously, it was approved only for those between the ages of nine and 26, and recommended for all children at age 11 or 12. “Today’s approval represents an important opportunity to help prevent HPV-related diseases and cancers in a broader age range,” Dr. Peter M...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
More teenagers than ever before are getting vaccinated against human papillomavirus (HPV), according to new data from the Centers for Disease Control and Prevention (CDC). Federal guidelines now say that all children should start two-dose HPV vaccination at age 11 or 12 to protect against HPV-associated cervical, vaginal, penile, anal and throat cancers. Despite that recommendation, however, HPV vaccination rates have traditionally lagged far below their targets. That’s still true — but the new report does suggest that rates are rising. Between 2016 and 2017, the CDC says, the percentage of teenagers who report...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
This study looks at a collection of studies looking at the benefit of HPV vaccines in reducing pre cervical cancer lesions.  HPV also causes many other serious cancers (especially head and neck).  In time, as more people have been vaccinated, we will see a reduction in all HPV cancers.  The HP V vaccine is one of a number of vaccines using virus like particles (VLPS) which have been shown to be very safe over the last 35 years. “The Cochrane library of reviews has a very rigorous assessment process of all their reviews. “The review only looked at cervical precancer (in women and girls),...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
ConclusionsOverall, the average direct medical cost of HPV infection was $720 per newborn. The economic burden of HPV remains significant, although changes in cervical screening guidelines, prompted by the introduction of a public HPV vaccine program, appear to have promoted a promising trend towards lower costs.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
CONCLUSION: Unvaccinated young Canadian women and men commonly engaged in sexual risk behaviours for HPV infection, engaged in sexual risk behaviours at a similar level as their vaccinated counterparts, and a substantial number were at elevated risk of HPV related morbidities at a young age. Findings contribute to an evidence-based case for redoubling efforts to encourage HPV vaccination among unvaccinated young Canadians who are at risk of HPV infection. PMID: 29276162 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Conclusion This study uses a large amount of national data to give us an idea about which groups of people have the greatest risk of carrying potentially cancer-causing oral HPV . But while oral HPV may increase people's risk of mouth and throat cancers, the actual number who would go on to develop cancer is extremely small. This study has limitations, which are worth bearing in mind: It only looked at whether people had oral HPV at a single point in time. This makes it difficult to know at what point they became infected and how much this could be down to other risk factors such as smoking, oral sex and number of partne...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Source Type: news
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