Mycobacterial Trehalose 6,6 ’-Dimycolate Induced M1-Type Inflammation

Murine models of Mycobacterium tuberculosis (Mtb) infection demonstrate progression of M1-like (pro-inflammatory) and M2-like (anti-inflammatory) macrophage morphology following primary granuloma formation. The Mtb cell wall cording factor, trehalose 6,6 ’-dimycolate (TDM), is a physiologically-relevant and useful molecule for modeling early macrophage-mediated events during establishment of the tuberculosis-induced granuloma pathogenesis. Here we show that TDM is a major driver of the early M1-like macrophage response as seen during initiation of the granulomas of primary pathology.

Source: American Journal of Pathology - November 13, 2019 Category: Pathology Authors: Thao K.T. Nguyen, John d ’Aigle, Luis Chinea, Zainab Niaz, Robert L. Hunter, Shen-An Hwang, Jeffrey K. Actor Tags: Short Communication Source Type: research